Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 4/20 | 0.44 |
| ▸ | CHRNA10 | Q9GZZ6 | 4/20 | 0.44 |
| ▸ | CHRNA9 | Q9UGM1 | 4/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL20923487 | 0.93 | SIGMAR1 (0.38) | CHRNA7CHRNA10CHRNA9SIGMAR1MAOA | |
| SCHEMBL5297631 | 0.92 | SIGMAR1 (0.39) | CHRNA7CHRNA10CHRNA9SIGMAR1MAOA | |
| Hydrochloric Acid SCHEMBL21082787 | 0.86 | CYP2D6 (0.39) | MAOA | |
| SCHEMBL8369382 | 0.84 | CYP2D6 (0.40) | MAOA | |
| SCHEMBL28185788 | 0.83 | SIGMAR1 (0.38) | HDAC1SIGMAR1HDAC4MAPT | |
| SCHEMBL2536679 | 0.79 | CHRNA7 (0.32) | CHRNA7CHRNA10CHRNA9 | |
| SCHEMBL19148658 | 0.78 | BCHE (0.42) | — | |
| SCHEMBL14802084 | 0.77 | BCHE (0.62) | CHRNA7CHRNA10CHRNA9 | |
| Bromide SCHEMBL19149563 | 0.76 | BCHE (0.44) | — | |
| Bromide SCHEMBL10456975 | 0.75 | BCHE (0.64) | CHRNA7CHRNA10CHRNA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10996496-B2 | Composite film, device including, and method of forming the same | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2021-05-04 | — | — | US | disclosed |
| EP-3500890-A1 | COMPOSITE FILM, DEVICE INCLUDING, AND METHOD OF FORMING THE SAME | Nanyang Technological University (SG) | 2019-06-26 | — | — | EP | disclosed |
| US-20190179176-A1 | COMPOSITE FILM, DEVICE INCLUDING, AND METHOD OF FORMING THE SAME | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2019-06-13 | — | — | US | disclosed |