Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | BCL2 | P10415 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10752466 | 0.83 | BCL2 (0.38) | ALDH1A1BCL2NPC1RAB9ACA12 | |
| SCHEMBL5961894 | 0.81 | BCL2 (0.37) | BCL2NPC1RAB9AMAPK14CA12 | |
| SCHEMBL8896547 | 0.80 | PRSS1 (0.32) | KDM4EALDH1A1BCL2 | |
| SCHEMBL6840996 | 0.80 | BCL2 (0.36) | BCL2CA12CA1CA2CA7 | |
| SCHEMBL6709391 | 0.75 | BCL2 (0.40) | KDM4EALDH1A1BCL2NPC1RAB9A | |
| SCHEMBL8924008 | 0.75 | — | — | |
| SCHEMBL3786646 | 0.75 | BCL2 (0.40) | KDM4EALDH1A1BCL2CA12CA1 | |
| SCHEMBL1999459 | 0.72 | BCL2 (0.41) | KDM4EALDH1A1BCL2RAB9ACA12 | |
| SCHEMBL5944757 | 0.72 | BCL2 (0.41) | KDM4EALDH1A1BCL2TSHRCA12 | |
| SCHEMBL877569 | 0.71 | BCL2 (0.40) | KDM4EALDH1A1BCL2TSHRCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12318403-B2 | 2′3′-cyclic dinucleotides and prodrugs thereof | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I. (CZ) | 2025-06-03 | — | — | US | disclosed |
| US-20250115629-A1 | CHIRAL SYNTHONS FOR THE SYNTHESIS OF CHIRAL PHOSPHOROTHIOATES | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2025-04-10 | — | — | US | disclosed |
| CN-111954675-B | 3' -Cyclic dinucleotides | 捷克共和国有机化学与生物化学研究所 | 2025-04-01 | — | — | CN | disclosed |
| CN-111954676-B | 2'3' -Cyclic dinucleotides | 捷克共和国有机化学与生物化学研究所 | 2025-01-24 | — | — | CN | disclosed |
| EP-4308580-A1 | CHIRAL SYNTHONS FOR THE SYNTHESIS OF CHIRAL PHOSPHOROTHIOATES | Boehringer Ingelheim International GmbH (DE) | 2024-01-24 | — | — | EP | disclosed |
| EP-3728282-B1 | 2'3' CYCLIC DINUCLEOTIDES WITH PHOSPHONATE BOND ACTIVATING THE STING ADAPTOR PROTEIN | INST OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR V V I (CZ) | 2023-11-22 | — | — | EP | disclosed |
| EP-3728283-B1 | 3'3' CYCLIC DINUCLEOTIDES WITH PHOSPHONATE BOND ACTIVATING THE STING ADAPTOR PROTEIN | INST OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR V V I (CZ) | 2023-11-22 | — | — | EP | disclosed |
| CN-116981677-A | Chiral synthons for synthesis of chiral phosphorothioates | 勃林格殷格翰国际有限公司 | 2023-10-31 | — | — | CN | disclosed |
| EP-3934757-B1 | 2'3'-CYCLIC DINUCLEOTIDES AND PRODRUGS THEREOF | INST OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR V V I (CZ) | 2023-02-22 | — | — | EP | disclosed |
| WO-2022194924-A1 | CHIRAL SYNTHONS FOR THE SYNTHESIS OF CHIRAL PHOSPHOROTHIOATES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2022-09-22 | — | — | WO | disclosed |
| EP-3728283-A1 | 3'3' CYCLIC DINUCLEOTIDES WITH PHOSPHONATE BOND ACTIVATING THE STING ADAPTOR PROTEIN | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. (CZ) | 2020-10-28 | — | — | EP | disclosed |
| US-20190322696-A1 | 3'3'-CYCLIC DINUCLEOTIDES | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR,V.V.I. (CZ) | 2019-10-24 | — | — | US | disclosed |
| US-20190322695-A1 | 2'3'-CYCLIC DINUCLEOTIDES | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR,V.V.I. (CZ) | 2019-10-24 | — | — | US | disclosed |
| US-20190322697-A1 | 2'2'-CYCLIC DINUCLEOTIDES | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR,V.V.I. (CZ) | 2019-10-24 | — | — | US | disclosed |
| WO-2019193542-A1 | 2'3'-CYCLIC DINUCLEOTIDES | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I. (CZ) | 2019-10-10 | — | — | WO | disclosed |
| WO-2019193543-A1 | 3'3'-CYCLIC DINUCLEOTIDES | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I. (CZ) | 2019-10-10 | — | — | WO | disclosed |
| WO-2019193533-A1 | 2'2'-CYCLIC DINUCLEOTIDES | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I. (CZ) | 2019-10-10 | — | — | WO | disclosed |
| US-20190183917-A1 | 3'3' CYCLIC DINUCLEOTIDES WITH PHOSPHONATE BOND ACTIVATING THE STING ADAPTOR PROTEIN | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I. (CZ) | 2019-06-20 | — | — | US | disclosed |
| US-20190185510-A1 | 2'3' CYCLIC DINUCLEOTIDES WITH PHOSPHONATE BOND ACTIVATING THE STING ADAPTOR PROTEIN | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I. (CZ) | 2019-06-20 | — | — | US | disclosed |
| US-20190185509-A1 | 2'2' CYCLIC DINUCLEOTIDES WITH PHOSPHONATE BOND ACTIVATING THE STING ADAPTOR PROTEIN | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I. (CZ) | 2019-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190322697-A1 | 2'2'-CYCLIC DINUCLEOTIDES | STING1, CGAS, MAVS | KDM4E 2659/4885ALDH1A1 4801/4885BCL2 3901/4885 |
| US-20190322695-A1 | 2'3'-CYCLIC DINUCLEOTIDES | STING1, MAVS, CGAS | KDM4E 2575/4885ALDH1A1 4795/4885BCL2 3914/4885 |
| US-20190185509-A1 | 2'2' CYCLIC DINUCLEOTIDES WITH PHOSPHONATE BOND ACTIVATING THE STING ADAPTOR PROTEIN | STING1, CGAS, TBK1 | KDM4E 2418/4885ALDH1A1 4794/4885BCL2 2401/4885 |
| US-12318403-B2 | 2′3′-cyclic dinucleotides and prodrugs thereof | STING1, CGAS, NT5C2 | KDM4E 2823/4885ALDH1A1 3309/4885BCL2 3321/4885 |
| US-20190322696-A1 | 3'3'-CYCLIC DINUCLEOTIDES | STING1, CGAS, MAVS | KDM4E 2572/4885ALDH1A1 4806/4885BCL2 4422/4885 |
| US-20190185510-A1 | 2'3' CYCLIC DINUCLEOTIDES WITH PHOSPHONATE BOND ACTIVATING THE STING ADAPTOR PROTEIN | STING1, CGAS, IRF3 | KDM4E 2531/4885ALDH1A1 4676/4885BCL2 3014/4885 |
| US-20250115629-A1 | CHIRAL SYNTHONS FOR THE SYNTHESIS OF CHIRAL PHOSPHOROTHIOATES | TYMP, RNGTT, TYMS | KDM4E 4616/4885ALDH1A1 3127/4885BCL2 4838/4885 |
| US-20190183917-A1 | 3'3' CYCLIC DINUCLEOTIDES WITH PHOSPHONATE BOND ACTIVATING THE STING ADAPTOR PROTEIN | STING1, IRF3, CGAS | KDM4E 2479/4885ALDH1A1 4735/4885BCL2 3767/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.