Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | CA5A | P35218 | 1/20 | 0.61 |
| ▸ | ENPP1 | P22413 | 4/20 | 0.56 |
| ▸ | P2RY1 | P47900 | 3/20 | 0.56 |
| ▸ | P2RY6 | Q15077 | 2/20 | 0.56 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.56 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.56 |
| ▸ | P2RY11 | Q96G91 | 1/20 | 0.56 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.56 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.55 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.54 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.54 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.53 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.53 |
| ▸ | GPR17 | Q13304 | 2/20 | 0.52 |
| ▸ | DTYMK | P23919 | 2/20 | 0.52 |
| ▸ | PNP | P00491 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29642033 | 0.93 | NT5E (0.64) | NT5EPOLBENPP1P2RY1P2RY6 | |
| SCHEMBL15573313 | 0.93 | NT5E (0.64) | NT5EPOLBENPP1P2RY1P2RY6 | |
| SCHEMBL23897688 | 0.92 | CA5A (0.71) | NT5EPOLBCA5AENPP1P2RY1 | |
| SCHEMBL20906977 | 0.92 | CA5A (0.71) | NT5EPOLBCA5AENPP1P2RY1 | |
| SCHEMBL23603472 | 0.92 | CA5A (0.71) | NT5EPOLBCA5AENPP1P2RY1 | |
| SCHEMBL345288 | 0.91 | NT5E (0.67) | NT5EPOLBENPP1P2RY1P2RY6 | |
| SCHEMBL4820794 | 0.91 | NT5E (0.67) | NT5EPOLBENPP1P2RY1P2RY6 | |
| SCHEMBL29400356 | 0.91 | NT5E (0.67) | NT5EPOLBENPP1P2RY1P2RY6 | |
| SCHEMBL17117823 | 0.91 | NT5E (0.67) | NT5EPOLBENPP1P2RY1P2RY6 | |
| SCHEMBL12932286 | 0.91 | NT5E (0.67) | NT5EPOLBENPP1P2RY1P2RY6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3728283-B1 | 3'3' CYCLIC DINUCLEOTIDES WITH PHOSPHONATE BOND ACTIVATING THE STING ADAPTOR PROTEIN | INST OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR V V I (CZ) | 2023-11-22 | — | — | EP | disclosed |
| EP-3728282-B1 | 2'3' CYCLIC DINUCLEOTIDES WITH PHOSPHONATE BOND ACTIVATING THE STING ADAPTOR PROTEIN | INST OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR V V I (CZ) | 2023-11-22 | — | — | EP | disclosed |
| US-20230303613-A1 | 3′3′ CYCLIC DINUCLEOTIDES WITH AN ALKENYLENE | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY AS CR, V.V.I. (CZ) | 2023-09-28 | — | — | US | disclosed |
| CN-111511754-B | 2'3' cyclic dinucleotides with phosphonate bonds of activated STING adaptor protein | 捷克共和国有机化学与生物化学研究所 | 2023-09-12 | — | — | CN | disclosed |
| EP-3936514-B1 | 3'3' CYCLIC DINUCLEOTIDES WITH AN ALKENYLENE | INST OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR V V I (CZ) | 2023-05-24 | — | — | EP | disclosed |
| WO-2022007986-A1 | 3'3' CYCLIC DINUCLEOTIDES WITH AN ALKENYLENE | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY AS CR, V. V. I. (CZ) | 2022-01-13 | — | — | WO | disclosed |
| EP-3936514-A1 | 3'3' CYCLIC DINUCLEOTIDES WITH AN ALKENYLENE | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. (CZ) | 2022-01-12 | — | — | EP | disclosed |
| US-11203610-B2 | 2′3′ cyclic dinucleotides with phosphonate bond activating the sting adaptor protein | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I. (CZ) | 2021-12-21 | — | — | US | disclosed |
| US-10966999-B2 | 3′3′ cyclic dinucleotides with phosphonate bond activating the sting adaptor protein | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I. (CZ) | 2021-04-06 | — | — | US | disclosed |
| EP-3728283-A1 | 3'3' CYCLIC DINUCLEOTIDES WITH PHOSPHONATE BOND ACTIVATING THE STING ADAPTOR PROTEIN | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. (CZ) | 2020-10-28 | — | — | EP | disclosed |
| EP-3728282-A1 | 2'3' CYCLIC DINUCLEOTIDES WITH PHOSPHONATE BOND ACTIVATING THE STING ADAPTOR PROTEIN | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. (CZ) | 2020-10-28 | — | — | EP | disclosed |
| US-20190183917-A1 | 3'3' CYCLIC DINUCLEOTIDES WITH PHOSPHONATE BOND ACTIVATING THE STING ADAPTOR PROTEIN | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I. (CZ) | 2019-06-20 | — | — | US | disclosed |
| US-20190185510-A1 | 2'3' CYCLIC DINUCLEOTIDES WITH PHOSPHONATE BOND ACTIVATING THE STING ADAPTOR PROTEIN | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I. (CZ) | 2019-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10966999-B2 | 3′3′ cyclic dinucleotides with phosphonate bond activating the sting adaptor protein | STING1, IRF3, MAVS | NT5E 566/4885POLB 489/4885CA5A 2456/4885 |
| US-11203610-B2 | 2′3′ cyclic dinucleotides with phosphonate bond activating the sting adaptor protein | STING1, CGAS, IRF3 | NT5E 419/4885POLB 345/4885CA5A 2289/4885 |
| US-20190185510-A1 | 2'3' CYCLIC DINUCLEOTIDES WITH PHOSPHONATE BOND ACTIVATING THE STING ADAPTOR PROTEIN | STING1, CGAS, IRF3 | NT5E 424/4885POLB 389/4885CA5A 2355/4885 |
| US-20230303613-A1 | 3′3′ CYCLIC DINUCLEOTIDES WITH AN ALKENYLENE | STING1, CGAS, IRF3 | NT5E 88/4885POLB 167/4885CA5A 1717/4885 |
| US-20190183917-A1 | 3'3' CYCLIC DINUCLEOTIDES WITH PHOSPHONATE BOND ACTIVATING THE STING ADAPTOR PROTEIN | STING1, IRF3, CGAS | NT5E 594/4885POLB 563/4885CA5A 2528/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.