Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 6/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 2/20 | 0.48 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | EIF4E | P06730 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3993564 | 0.84 | PHGDH (0.63) | PHGDHHPGDPKMAKR1C3HDAC4 | |
| SCHEMBL2929014 | 0.80 | PHGDH (0.57) | PHGDHHPGDPKMAKR1C3HDAC4 | |
| SCHEMBL20576422 | 0.78 | XDH (0.52) | HPGDALDH1A1LMNATSHRMAPK1 | |
| SCHEMBL798155 | 0.77 | PHGDH (0.60) | PHGDHHPGDPKMAKR1C3ALDH1A1 | |
| SCHEMBL21058661 | 0.76 | ACACB (0.44) | PHGDHHPGDPKMAKR1C3JAK2 | |
| SCHEMBL10720943 | 0.75 | PHGDH (0.81) | PHGDHHPGDPKMAKR1C3ALDH1A1 | |
| (4-Chlorophenyl)(Morpholino)Methanone SCHEMBL6937394 | 0.74 | PHGDH (1.00) | PHGDHHPGDPKMAKR1C3ALDH1A1 | |
| SCHEMBL3998737 | 0.73 | JAK2 (0.52) | PHGDHHPGDPKMAKR1C3JAK2 | |
| SCHEMBL8172365 | 0.73 | EPHX2 (0.71) | PHGDHHPGDAKR1C3HDAC4TSHR | |
| SCHEMBL7380246 | 0.73 | MAP4K4 (0.51) | HPGDALDH1A1LMNAMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190185456-A1 | INHIBITORS OF INFLUENZA VIRUS REPLICATION, APPLICATION METHODS AND USES THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2019-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190185456-A1 | INHIBITORS OF INFLUENZA VIRUS REPLICATION, APPLICATION METHODS AND USES THEREOF | POLRMT, EIF2AK2, POLM | PHGDH 2830/4885HPGD 1750/4885PKM 2119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.