Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 8/20 | 0.66 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.56 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.55 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.55 |
| ▸ | GCK | P35557 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30498440 | 1.00 | HCAR3 (0.66) | HCAR3NPC1RAB9AALDH1A1DEGS1 | |
| SCHEMBL5239807 | 0.94 | HCAR3 (0.68) | HCAR3NPC1RAB9AALDH1A1GCK | |
| SCHEMBL5233530 | 0.92 | HCAR3 (0.66) | HCAR3NPC1RAB9AALDH1A1GCK | |
| SCHEMBL5738821 | 0.86 | HCAR3 (0.54) | HCAR3NPC1RAB9AALDH1A1DEGS1 | |
| SCHEMBL3466282 | 0.85 | NNMT (0.58) | NPC1RAB9AALDH1A1DEGS1 | |
| SCHEMBL25702959 | 0.81 | NPC1 (0.51) | NPC1RAB9AALDH1A1DEGS1 | |
| SCHEMBL5740731 | 0.81 | HCAR3 (0.56) | HCAR3NPC1RAB9AGCK | |
| SCHEMBL18839009 | 0.80 | NPC1 (0.50) | NPC1RAB9AALDH1A1DEGS1 | |
| SCHEMBL18839006 | 0.80 | NPC1 (0.50) | NPC1RAB9AALDH1A1DEGS1 | |
| SCHEMBL5233668 | 0.80 | NPC1 (0.57) | HCAR3NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3724197-A1 | FUSED PYRIDINES WHICH ACT AS INHIBITORS OF H-PGDS | GlaxoSmithKline Intellectual Property Development Ltd (GB) | 2020-10-21 | — | — | EP | disclosed |
| WO-2019116256-A1 | FUSED PYRIDINES WHICH ACT AS INHIBITORS OF H-PGDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-06-20 | — | — | WO | disclosed |