Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.57 |
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | ATF4 | P18848 | 2/20 | 0.51 |
| ▸ | PIM1 | P11309 | 2/20 | 0.48 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.47 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30578688 | 1.00 | RAB9A (0.57) | RAB9ANPC1ATF4PIM1PIM2 | |
| Hydrochloric Acid SCHEMBL21050122 | 0.99 | RAB9A (0.56) | RAB9ANPC1ATF4PIM1PIM2 | |
| Trifluoroacetic Acid SCHEMBL21819415 | 0.92 | RAB9A (0.50) | RAB9ANPC1ATF4PIM1PIM2 | |
| SCHEMBL24225638 | 0.87 | RAB9A (0.73) | RAB9ANPC1ATF4HDAC3HDAC4 | |
| SCHEMBL17209555 | 0.87 | RAB9A (0.73) | RAB9ANPC1ATF4HDAC3HDAC4 | |
| SCHEMBL30578714 | 0.86 | RAB9A (0.58) | RAB9ANPC1ATF4HDAC3HDAC4 | |
| SCHEMBL21050136 | 0.86 | RAB9A (0.58) | RAB9ANPC1ATF4HDAC3HDAC4 | |
| SCHEMBL30578689 | 0.86 | RAB9A (0.58) | RAB9ANPC1ATF4HDAC3HDAC4 | |
| SCHEMBL24225649 | 0.86 | RAB9A (0.58) | RAB9ANPC1ATF4HDAC3HDAC4 | |
| SCHEMBL6337803 | 0.84 | MCHR1 (0.59) | RAB9ANPC1MAPTKDM4ENR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023231948-A1 | ISR INHIBITORS, METHOD FOR PREPARING SAME, AND USE THEREOF | 中国药科大学 | 2023-12-07 | — | — | WO | disclosed |
| CN-116768877-A | ISR inhibitor and preparation method and application thereof | 中国药科大学 | 2023-09-19 | — | — | CN | disclosed |
| EP-3723762-A2 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | Praxis Biotech LLC (US) | 2020-10-21 | — | — | EP | disclosed |
| WO-2019118785-A2 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | Praxis Biotech LLC (US) | 2019-06-20 | — | — | WO | disclosed |