Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.36 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18765254 | 0.77 | GPR119 (0.39) | USP30KDM4ENR1H2RORCGPR119 | |
| SCHEMBL31704738 | 0.76 | EED (0.50) | KDM4EGPR119MAPTTHRBMEN1 | |
| SCHEMBL2279416 | 0.75 | KDM4E (0.48) | USP30KDM4EGPR119HPGDSMAPT | |
| SCHEMBL25900920 | 0.75 | KDM4E (0.41) | USP30KDM4ENR1H2FEN1GPR119 | |
| SCHEMBL3466672 | 0.74 | KDM4E (0.46) | USP30KDM4ERORCGPR119HPGDS | |
| SCHEMBL20163062 | 0.74 | CKS1B (0.52) | GPR119MAPTALDH1A1 | |
| SCHEMBL27188465 | 0.74 | KDM4E (0.43) | KDM4ENR1H2RORCGPR119MAPT | |
| SCHEMBL31284927 | 0.74 | GRM1 (0.41) | USP30GPR119ADORA1 | |
| SCHEMBL9947823 | 0.74 | HSD11B1 (0.44) | USP30KDM4ENR1H2GPR119MAPT | |
| SCHEMBL23705673 | 0.73 | TRPV3 (0.46) | USP30KDM4EFEN1HPGDSMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019118612-A1 | TARGETING COMPOUNDS | ZAFGEN, INC. (US) | 2019-06-20 | — | — | WO | disclosed |
| WO-2019118612-A1 | TARGETING COMPOUNDS | ZAFGEN, INC. (US) | 2019-06-20 | — | — | WO | disclosed |