Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15830040 | 0.78 | CYP1A2 (0.52) | MAPK1MALT1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL21064115 | 0.75 | MAPK1 (0.54) | MAPK1MAPK8MAPK9MAPK10IDH1 | |
| SCHEMBL19462069 | 0.75 | MAPK1 (0.49) | MAPK1MALT1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL18072377 | 0.75 | HRH3 (0.68) | MAPK1MALT1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL17072658 | 0.74 | MAPK1 (0.45) | MAPK1MALT1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL18466258 | 0.74 | MALT1 (0.57) | MAPK1MALT1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL30158688 | 0.74 | MAPK14 (0.46) | MAPK1MALT1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL21297272 | 0.71 | MAPK14 (0.52) | MAPK1ALDH1A1MAPK14CSNK1DLRRK2 | |
| SCHEMBL20252330 | 0.70 | MAPK14 (0.41) | MAPK1ALDH1A1MAPK14CSNK1DLRRK2 | |
| SCHEMBL828268 | 0.69 | ALDH1A1 (0.71) | MAPK1ALDH1A1MAPK14CSNK1DLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10307413-B2 | Tetrahydro- and dihydro-isoquinoline PRMT5 inhibitors and uses thereof | Epizyme, Inc. (US) | 2019-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10307413-B2 | Tetrahydro- and dihydro-isoquinoline PRMT5 inhibitors and uses thereof | PRMT5, PRMT1, PRMT3 | MAPK1 1357/4885MALT1 2773/4885CYP1A2 1690/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.