Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 12/20 | 0.54 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.48 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 4/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
| ▸ | CCNC | P24863 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | CDK7 | P50613 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | CCNH | P51946 | 1/20 | 0.44 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.41 |
| ▸ | MAPK3 | P27361 | 3/20 | 0.41 |
| ▸ | IDH1 | O75874 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14004978 | 0.89 | MAPK1 (0.57) | MAPK1HRH4MKNK1MKNK2MAPK8 | |
| SCHEMBL15830033 | 0.78 | MAPK1 (0.62) | MAPK1HRH4MKNK1MKNK2MAPK8 | |
| SCHEMBL83995 | 0.77 | CDK4 (0.47) | HRH4CDK2CDK7CDK9CCNA2 | |
| SCHEMBL16220909 | 0.75 | MAPK1 (0.58) | MAPK1HRH4MKNK1MKNK2MAPK8 | |
| SCHEMBL21064113 | 0.75 | MAPK1 (0.43) | MAPK1HRH4MAPK8MAPK9MAPK10 | |
| SCHEMBL10188247 | 0.75 | MAPK1 (0.62) | MAPK1HRH4MKNK1MKNK2MAPK10 | |
| SCHEMBL84414 | 0.75 | CDK1 (0.54) | HRH4MKNK2MAPK8MAPK9RET | |
| SCHEMBL19171094 | 0.74 | MAPK1 (0.57) | MAPK1HRH4MKNK1MKNK2MAPK8 | |
| SCHEMBL24824411 | 0.74 | CCNT1 (0.49) | MAPK1MKNK1MKNK2CDK2CCNT1 | |
| SCHEMBL84078 | 0.74 | CDK1 (0.56) | HRH4MKNK2MAPK8MAPK9RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10307413-B2 | Tetrahydro- and dihydro-isoquinoline PRMT5 inhibitors and uses thereof | Epizyme, Inc. (US) | 2019-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10307413-B2 | Tetrahydro- and dihydro-isoquinoline PRMT5 inhibitors and uses thereof | PRMT5, PRMT1, PRMT3 | MAPK1 1357/4885HRH4 530/4885MKNK1 345/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.