Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | NAAA | Q02083 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16708938 | 1.00 | ALDH1A1 (0.51) | ALDH1A1TSHRMEN1KMT2AGAA | |
| SCHEMBL640932 | 0.86 | GAA (0.46) | ALDH1A1TSHRMEN1KMT2AGAA | |
| Hydrochloric Acid SCHEMBL641426 | 0.85 | GAA (0.46) | ALDH1A1TSHRMEN1KMT2AGAA | |
| SCHEMBL16708942 | 0.84 | ESR2 (0.52) | ALDH1A1TSHRMEN1KMT2AGAA | |
| SCHEMBL21065269 | 0.84 | ESR2 (0.52) | ALDH1A1TSHRMEN1KMT2AGAA | |
| SCHEMBL2722626 | 0.84 | NAAA (0.53) | ALDH1A1SMN1; SMN2NPC1RAB9ANAAA | |
| SCHEMBL2722339 | 0.84 | NAAA (0.53) | ALDH1A1SMN1; SMN2NPC1RAB9ANAAA | |
| SCHEMBL2722341 | 0.84 | NAAA (0.53) | ALDH1A1SMN1; SMN2NPC1RAB9ANAAA | |
| SCHEMBL9195822 | 0.83 | MEN1 (0.51) | ALDH1A1TSHRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9195825 | 0.83 | MEN1 (0.51) | ALDH1A1TSHRMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10689357-B2 | N-acylethanolamine hydrolyzing acid amidase (NAAA) inhibitors and use thereof | NORTHEASTERN UNIVERSITY (US) | 2020-06-23 | — | — | US | disclosed |
| US-20190345132-A1 | N-Acylethanolamine Hydrolyzing Acid Amidase (NAAA) Inhibitors And Use Thereof | NORTHEASTERN UNIVERSITY | 2019-11-14 | — | — | US | disclosed |
| WO-2019217977-A1 | N-ACYLETHANOLAMINE HYDROLYZING ACID AMIDASE (NAAA) INHIBITORS AND USE THEREOF | NORTHEASTERN UNIVERSITY (US) | 2019-11-14 | — | — | WO | disclosed |
| EP-3068785-B1 | SUBSTITUTED 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS CASEIN KINASE 1 D/E INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2019-06-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10689357-B2 | N-acylethanolamine hydrolyzing acid amidase (NAAA) inhibitors and use thereof | NAAA, NAT1, ACHE | ALDH1A1 848/4885TSHR 3856/4885MEN1 3960/4885 |
| US-20190345132-A1 | N-Acylethanolamine Hydrolyzing Acid Amidase (NAAA) Inhibitors And Use Thereof | NAAA, NAT1, ACHE | ALDH1A1 848/4885TSHR 3856/4885MEN1 3960/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.