SCHEMBL2106579

SCHEMBL2106579

Cc1[c]c(C)c(-c2ccc([N+](=O)[O-])cc2)c(C(F)(C(F)(F)F)C(F)(F)C(F)(F)F)c1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.36
AKR1C3 P42330 2/20 0.34
AKR1C2 P52895 2/20 0.34
ACHE P22303 1/20 0.34
HSD17B10 Q99714 1/20 0.34
PSD A5PKW4 3/20 0.33
MMP2 P08253 1/20 0.33
MMP9 P14780 1/20 0.33
MMP8 P22894 1/20 0.33
MMP13 P45452 1/20 0.33
MEN1 O00255 1/20 0.33
GAA P10253 1/20 0.33
MAPT P10636 1/20 0.33
HTT P42858 1/20 0.33
KMT2A Q03164 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
HSD11B1 P28845 1/20 0.32
TSHR P16473 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
AR P10275 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1948387 0.94 ALDH1A1 (0.38) ALDH1A1AKR1C3AKR1C2ACHEHSD17B10
SCHEMBL17554983 0.88 ALDH1A1 (0.34) ALDH1A1AKR1C3AKR1C2ACHEHSD17B10
SCHEMBL2105230 0.87 MEN1 (0.38) ALDH1A1AKR1C3AKR1C2ACHEMMP2
SCHEMBL2103791 0.83 AR (0.31) AR
SCHEMBL2104340 0.82
SCHEMBL17554900 0.81 ALDH1A1 (0.36) ALDH1A1AKR1C3AKR1C2ACHEHSD17B10
SCHEMBL2105506 0.81 PTGS2 (0.33) HTT
SCHEMBL2105100 0.79 ALDH1A1 (0.34) ALDH1A1AKR1C3AKR1C2ACHEHSD17B10
SCHEMBL2106091 0.79 ALDH1A1 (0.35) ALDH1A1HSD17B10MEN1GAAMAPT
SCHEMBL16462365 0.79 AKR1C3 (0.35) ALDH1A1AKR1C3AKR1C2PSDMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8163804-B2 Composition for preventing harmful organisms MITSUI CHEMICALS, INC. (JP) 2012-04-24 US disclosed
US-20090162453-A1 COMPOSITION FOR PREVENTING HARMFUL ORGANISMS MITSUI CHEMICALS, INC (JP) 2009-06-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090162453-A1 COMPOSITION FOR PREVENTING HARMFUL ORGANISMS PRDX3, CYP1A1, GSTA1 ALDH1A1 406/4885AKR1C3 68/4885AKR1C2 259/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.