Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 5/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 10/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21775922 | 0.80 | DRD3 (0.41) | DRD3SLC6A2SLC6A4DRD2ADRA1A | |
| SCHEMBL21775889 | 0.78 | DRD3 (0.40) | DRD3SLC6A2SLC6A4DRD2ADRA1A | |
| SCHEMBL20389575 | 0.73 | DRD2 (0.66) | DRD3SLC6A2SLC6A4DRD2ADRA1A | |
| SCHEMBL23721734 | 0.69 | DRD3 (0.54) | DRD3DRD2HTR1AHTR2A | |
| SCHEMBL14764833 | 0.69 | HTR1A (0.58) | DRD3SLC6A2SLC6A4DRD2ADRA1A | |
| SCHEMBL23721736 | 0.69 | DRD3 (0.53) | DRD3DRD2HTR1AHTR2A | |
| SCHEMBL23729115 | 0.69 | DRD2 (0.50) | DRD3SLC6A2SLC6A4DRD2ADRA1A | |
| SCHEMBL23721371 | 0.68 | DRD3 (0.53) | DRD3DRD2HTR1AHTR2A | |
| SCHEMBL23721818 | 0.68 | DRD3 (0.52) | DRD3DRD2HTR1AHTR2A | |
| SCHEMBL23721092 | 0.67 | DRD3 (0.51) | DRD3DRD2HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190167672-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2019-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190167672-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | SUZ12, BRPF3, BRD4 | DRD3 902/4885SLC6A2 108/4885SLC6A4 24/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.