Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 8/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.47 |
| ▸ | RELA | Q04206 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.47 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL211214 | 0.85 | HDAC1 (0.74) | HDAC1HDAC2HDAC3HDAC8CSNK2A2 | |
| SCHEMBL5583353 | 0.80 | SMN1; SMN2 (0.65) | HDAC1MAPTSMN1; SMN2TP53NPC1 | |
| SCHEMBL2091539 | 0.72 | RORC (0.57) | MAPTSMN1; SMN2TP53NPC1RAB9A | |
| SCHEMBL1988015 | 0.72 | APP (0.69) | MAPTSMN1; SMN2TP53NPC1RAB9A | |
| SCHEMBL22389485 | 0.72 | RAB9A (0.66) | MAPTSMN1; SMN2TP53NPC1RAB9A | |
| SCHEMBL15271195 | 0.72 | SCD (0.74) | HDAC1MAPTSMN1; SMN2TP53NPC1 | |
| SCHEMBL3947598 | 0.72 | NPC1 (0.62) | MAPTSMN1; SMN2TP53NPC1RAB9A | |
| SCHEMBL2192719 | 0.72 | NPC1 (0.54) | MAPTTP53NPC1RAB9AHDAC6 | |
| SCHEMBL2733518 | 0.71 | HDAC1 (0.58) | HDAC1CSNK2A2CSNK2BCSNK2A1CSNK2A3 | |
| SCHEMBL30795308 | 0.71 | SCD (0.73) | HDAC1MAPTSMN1; SMN2TP53NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088805-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2012-01-03 | — | — | US | disclosed |