Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.49 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13596969 | 1.00 | DPP4 (0.55) | DPP4L3MBTL1L3MBTL3SLC6A9OPRM1 | |
| SCHEMBL13597006 | 0.90 | DPP4 (0.49) | DPP4L3MBTL1L3MBTL3SLC6A9OPRM1 | |
| SCHEMBL13597004 | 0.90 | L3MBTL1 (0.56) | DPP4L3MBTL1L3MBTL3OPRM1CHRM2 | |
| SCHEMBL85392 | 0.86 | OPRM1 (0.48) | DPP4L3MBTL1L3MBTL3SLC6A9OPRM1 | |
| SCHEMBL14026665 | 0.85 | CYP2D6 (0.55) | DPP4OPRM1CHRM4ADRA2ACYP2D6 | |
| SCHEMBL10280648 | 0.85 | CYP2D6 (0.55) | DPP4OPRM1CHRM4ADRA2ACYP2D6 | |
| SCHEMBL13596973 | 0.84 | DPP4 (0.67) | DPP4L3MBTL1L3MBTL3SLC6A9OPRM1 | |
| SCHEMBL5633486 | 0.83 | DPP4 (0.51) | DPP4L3MBTL1L3MBTL3SLC6A9OPRM1 | |
| SCHEMBL14459926 | 0.83 | DPP4 (0.48) | DPP4L3MBTL1L3MBTL3SLC6A9OPRM1 | |
| SCHEMBL5633154 | 0.83 | LMNA (0.48) | DPP4L3MBTL1L3MBTL3SLC6A9OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3166939-B1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH INC (US) | 2019-06-05 | — | — | EP | disclosed |