Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | UBE2M | P61081 | 1/20 | 0.39 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.39 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21075227 | 0.86 | L3MBTL1 (0.53) | KCNH2CACNA1IL3MBTL1ACHEKDM4E | |
| SCHEMBL19083894 | 0.85 | ACHE (0.50) | KCNH2CACNA1ICYP2D6CYP3A4USP2 | |
| SCHEMBL19075613 | 0.83 | MGAT2 (0.45) | KCNH2CACNA1ICYP2D6CYP3A4USP2 | |
| SCHEMBL19075615 | 0.78 | CYP2D6 (0.49) | KCNH2CYP2D6CYP3A4USP2CYP1A2 | |
| SCHEMBL19084132 | 0.77 | CYP2D6 (0.51) | KCNH2CYP2D6CYP3A4USP2CYP1A2 | |
| SCHEMBL19075643 | 0.77 | RORC (0.42) | KDM4EALDH1A1DCUN1D1TACR1 | |
| SCHEMBL19083685 | 0.76 | CYP2D6 (0.52) | KCNH2CYP2D6CYP3A4USP2CYP1A2 | |
| SCHEMBL19075619 | 0.75 | SLC6A2 (0.47) | KDM4EALDH1A1DCUN1D1 | |
| SCHEMBL23118445 | 0.74 | CYP2D6 (0.50) | KCNH2CYP2D6CYP3A4USP2CYP1A2 | |
| SCHEMBL20697685 | 0.74 | ALOX5AP (0.44) | UBE2MDCUN1D1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3166939-B1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH INC (US) | 2019-06-05 | — | — | EP | disclosed |