Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 7/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.36 |
| ▸ | DRD4 | P21917 | 3/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | IDH2 | P48735 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19083939 | 0.87 | TACR1 (0.45) | TACR1SLC6A4KCNH2GRM2DRD4 | |
| SCHEMBL21075333 | 0.86 | KCNH2 (0.44) | TACR1SLC6A4KCNH2SIGMAR1 | |
| SCHEMBL19075523 | 0.85 | KCNH2 (0.44) | TACR1SLC6A4KCNH2GRM2DRD4 | |
| SCHEMBL21075802 | 0.84 | TACR1 (0.49) | TACR1SLC6A4KCNH2 | |
| SCHEMBL6945302 | 0.74 | CYP2D6 (0.52) | SIGMAR1 | |
| SCHEMBL17061916 | 0.74 | TACR1 (0.46) | TACR1SLC6A4KCNH2 | |
| SCHEMBL16770692 | 0.74 | TACR1 (0.46) | TACR1SLC6A4KCNH2 | |
| SCHEMBL4023227 | 0.73 | KCNH2 (0.45) | TACR1SLC6A4KCNH2 | |
| SCHEMBL4021955 | 0.73 | TACR1 (0.45) | TACR1SLC6A4KCNH2GRM2 | |
| SCHEMBL17069228 | 0.71 | TACR1 (0.44) | TACR1SLC6A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3166939-B1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH INC (US) | 2019-06-05 | — | — | EP | disclosed |