Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 7/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21075333 | 0.86 | KCNH2 (0.44) | TACR1SLC6A4KCNH2MEN1KMT2A | |
| SCHEMBL21075678 | 0.84 | TACR1 (0.43) | TACR1SLC6A4KCNH2 | |
| SCHEMBL19083939 | 0.84 | TACR1 (0.45) | TACR1SLC6A4KCNH2KMT2AHRH3 | |
| SCHEMBL19075523 | 0.82 | KCNH2 (0.44) | TACR1SLC6A4KCNH2CYP3A4 | |
| SCHEMBL16770692 | 0.74 | TACR1 (0.46) | TACR1SLC6A4KCNH2MEN1KMT2A | |
| SCHEMBL17061916 | 0.74 | TACR1 (0.46) | TACR1SLC6A4KCNH2MEN1KMT2A | |
| SCHEMBL4021955 | 0.73 | TACR1 (0.45) | TACR1SLC6A4KCNH2MEN1KMT2A | |
| SCHEMBL4023227 | 0.73 | KCNH2 (0.45) | TACR1SLC6A4KCNH2MEN1KMT2A | |
| SCHEMBL17069228 | 0.71 | TACR1 (0.44) | TACR1SLC6A4KCNH2 | |
| SCHEMBL19262510 | 0.70 | CYP2D6 (0.72) | TACR1CYP3A4CYP2D6ADRB1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3166939-B1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH INC (US) | 2019-06-05 | — | — | EP | disclosed |