SCHEMBL4023227

SCHEMBL4023227

OCCc1cc(C(F)(F)F)cc(C2CC2)n1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 8/20 0.45
TACR1 P25103 7/20 0.45
SLC6A4 P31645 7/20 0.45
GABRA2 P47869 1/20 0.33
GABRB2 P47870 1/20 0.33
GAA P10253 2/20 0.33
HPGD P15428 2/20 0.33
TDP1 Q9NUW8 2/20 0.33
L3MBTL1 Q9Y468 2/20 0.33
IDO1 P14902 2/20 0.33
CTSK P43235 1/20 0.33
KDM4E B2RXH2 1/20 0.33
MEN1 O00255 1/20 0.33
ALDH1A1 P00352 1/20 0.33
LMNA P02545 1/20 0.33
KMT2A Q03164 1/20 0.33
TDO2 P48775 1/20 0.33
SRC P12931 1/20 0.32
ZAP70 P43403 1/20 0.32
SYK P43405 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4021955 0.84 TACR1 (0.45) KCNH2TACR1SLC6A4GABRA2GABRB2
SCHEMBL16770692 0.82 TACR1 (0.46) KCNH2TACR1SLC6A4GABRA2GABRB2
SCHEMBL17061916 0.82 TACR1 (0.46) KCNH2TACR1SLC6A4GABRA2GABRB2
SCHEMBL17069228 0.78 TACR1 (0.44) KCNH2TACR1SLC6A4GABRA2GABRB2
SCHEMBL21075333 0.75 KCNH2 (0.44) KCNH2TACR1SLC6A4GABRA2GABRB2
SCHEMBL21075678 0.73 TACR1 (0.43) KCNH2TACR1SLC6A4
SCHEMBL21075802 0.73 TACR1 (0.49) KCNH2TACR1SLC6A4MEN1KMT2A
SCHEMBL19083939 0.73 TACR1 (0.45) KCNH2TACR1SLC6A4HPGDKMT2A
SCHEMBL31170813 0.73 TACR1 (0.38) KCNH2TACR1SLC6A4GABRA2GABRB2
SCHEMBL561532 0.73 GABRA2 (0.46) KCNH2TACR1SLC6A4GABRA2GABRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009096941-A1 SUBSTITUTED HETEROCYCLIC ETHERS AND THEIR USE IN CNS DISORDERS BRISTOL-MYERS SQUIBB COMPANY (US) 2009-08-06 WO disclosed
EP-2069328-A2 4-ARYLALKOXYMETHYL-4-PHENYL PIPERIDINES AND THEIR USE AS NEUROKININ RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CNS DISORDERS Brystol-Myers Squibb Company (US) 2009-06-17 EP disclosed
WO-2008014247-A2 4 -ARYLALKOXYMETHYL-4- PHENYL PIPERIDINES AND THEIR USE AS NEUROKININ RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CNS DISORDERS BRISTOL-MYERS SQUIBB COMPANY (US) 2008-01-31 WO disclosed