Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 9/20 | 0.44 |
| ▸ | TACR1 | P25103 | 7/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP5 | P51878 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19083939 | 0.86 | TACR1 (0.45) | KCNH2TACR1SLC6A4KMT2AHPGD | |
| SCHEMBL21075678 | 0.86 | TACR1 (0.43) | KCNH2TACR1SLC6A4SIGMAR1 | |
| SCHEMBL21075802 | 0.86 | TACR1 (0.49) | KCNH2TACR1SLC6A4KMT2AMEN1 | |
| SCHEMBL19075523 | 0.84 | KCNH2 (0.44) | KCNH2TACR1SLC6A4 | |
| SCHEMBL17061916 | 0.76 | TACR1 (0.46) | KCNH2TACR1SLC6A4ALDH1A1KDM4E | |
| SCHEMBL16770692 | 0.76 | TACR1 (0.46) | KCNH2TACR1SLC6A4ALDH1A1KDM4E | |
| SCHEMBL4023227 | 0.75 | KCNH2 (0.45) | KCNH2TACR1SLC6A4ALDH1A1KDM4E | |
| SCHEMBL4021955 | 0.75 | TACR1 (0.45) | KCNH2TACR1SLC6A4ALDH1A1KDM4E | |
| SCHEMBL17069228 | 0.72 | TACR1 (0.44) | KCNH2TACR1SLC6A4GABRA2GABRB2 | |
| SCHEMBL561532 | 0.71 | GABRA2 (0.46) | KCNH2TACR1SLC6A4ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3166939-B1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH INC (US) | 2019-06-05 | — | — | EP | disclosed |