Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.49 |
| ▸ | DRD4 | P21917 | 2/20 | 0.49 |
| ▸ | DRD3 | P35462 | 2/20 | 0.49 |
| ▸ | OPRL1 | P41146 | 13/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 12/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 12/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 12/20 | 0.45 |
| ▸ | PKLR | P30613 | 2/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16565590 | 0.82 | OPRL1 (0.51) | DRD2DRD4DRD3OPRL1OPRM1 | |
| SCHEMBL27035066 | 0.79 | HDAC4 (0.49) | DRD2DRD4DRD3OPRL1OPRM1 | |
| SCHEMBL17886563 | 0.78 | OPRM1 (0.47) | DRD2DRD4DRD3OPRL1OPRM1 | |
| SCHEMBL8986019 | 0.77 | HDAC4 (0.51) | DRD2DRD4DRD3OPRL1OPRM1 | |
| SCHEMBL30089861 | 0.77 | HDAC4 (0.51) | DRD2DRD4DRD3OPRL1OPRM1 | |
| SCHEMBL23210134 | 0.74 | OPRM1 (0.44) | DRD2DRD4DRD3OPRL1OPRM1 | |
| SCHEMBL29691231 | 0.74 | OPRM1 (0.44) | DRD2DRD4DRD3OPRL1OPRM1 | |
| SCHEMBL652087 | 0.74 | SIGMAR1 (0.57) | DRD2DRD4DRD3OPRL1OPRM1 | |
| SCHEMBL7109502 | 0.73 | DRD2 (0.54) | DRD2DRD4DRD3OPRL1OPRM1 | |
| SCHEMBL7237487 | 0.73 | DRD2 (0.60) | DRD2DRD4DRD3OPRL1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |