Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 10/20 | 0.58 |
| ▸ | HTR2A | P28223 | 2/20 | 0.56 |
| ▸ | HTR2C | P28335 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.48 |
| ▸ | CCR5 | P51681 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CCR3 | P51677 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25498560 | 0.84 | LMNA (0.65) | MCHR1PDK2CCR5LMNA | |
| SCHEMBL12082859 | 0.84 | PDK2 (0.61) | MCHR1HTR2AHTR2CJAK2JAK1 | |
| SCHEMBL94337 | 0.82 | MCHR1 (0.50) | MCHR1PDK2CCR5LMNA | |
| SCHEMBL16553814 | 0.82 | HTR2A (0.54) | MCHR1HTR2AHTR2CJAK2JAK1 | |
| SCHEMBL1164100 | 0.82 | MCHR1 (0.50) | MCHR1PDK2CCR5LMNA | |
| SCHEMBL3329900 | 0.82 | CCR5 (0.55) | MCHR1HTR2AHTR2CJAK2JAK1 | |
| SCHEMBL17886830 | 0.80 | HTR2A (0.56) | MCHR1HTR2AHTR2CPDK2LMNA | |
| SCHEMBL15088420 | 0.80 | MCHR1 (0.67) | MCHR1HTR2AHTR2CJAK2JAK1 | |
| SCHEMBL28506409 | 0.80 | MCHR1 (0.48) | MCHR1PDK2CCR5LMNA | |
| SCHEMBL1448084 | 0.79 | MCHR1 (0.47) | MCHR1JAK2JAK1PDK2CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |