Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.40 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.40 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21078137 | 0.85 | SLC6A4 (0.41) | HSD11B1OPRM1P2RX7EPHX2LMNA | |
| SCHEMBL16565921 | 0.84 | P2RX7 (0.53) | HSD11B1OPRM1P2RX7KMT2A | |
| SCHEMBL4866308 | 0.82 | DPP4 (0.58) | MAOAMAOBTAAR1HSD11B1DPP4 | |
| SCHEMBL17886575 | 0.81 | OPRM1 (0.58) | MAOAMAOBTAAR1HSD11B1NPFFR1 | |
| SCHEMBL3934544 | 0.81 | NPFFR1 (0.60) | NPFFR1NPFFR2OPRM1TSHRLMNA | |
| SCHEMBL17761202 | 0.80 | DPP4 (0.56) | MAOAMAOBTAAR1HSD11B1DPP4 | |
| SCHEMBL21078099 | 0.78 | MAOB (0.68) | MAOAMAOBTAAR1OPRM1DPP4 | |
| SCHEMBL6628915 | 0.78 | CHRM2 (0.43) | MAOAMAOBTAAR1NPFFR1NPFFR2 | |
| SCHEMBL4760898 | 0.78 | TACR1 (0.49) | MAOAMAOBTAAR1HSD11B1OPRM1 | |
| SCHEMBL4033607 | 0.76 | NPC1 (0.57) | EPHX2TSHRL3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |