Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 14/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | GPR183 | P32249 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21078128 | 0.91 | NAMPT (0.50) | NAMPTGRM5 | |
| SCHEMBL21078112 | 0.89 | HPGD (0.42) | NAMPTGRM5KDM4EALDH1A1LMNA | |
| SCHEMBL21078144 | 0.86 | KEAP1 (0.44) | NAMPTGRM5MAPTALDH1A1HPGD | |
| SCHEMBL21077918 | 0.86 | ALDH1A1 (0.48) | NAMPTALDH1A1 | |
| SCHEMBL21077905 | 0.84 | ALDH1A1 (0.52) | NAMPTALDH1A1HPGD | |
| SCHEMBL17888258 | 0.82 | NAMPT (0.51) | NAMPTGRM5GPR183KCNH2MAPT | |
| SCHEMBL17886596 | 0.79 | MAPT (0.47) | NAMPTGRM5MAPTCNR2 | |
| SCHEMBL31558700 | 0.79 | NAMPT (0.47) | NAMPTGRM5GPR183KCNH2MAPT | |
| SCHEMBL21078110 | 0.78 | JAK1 (0.37) | NAMPTGRM5KDM4EALDH1A1HPGD | |
| SCHEMBL21078107 | 0.76 | AKR1C3 (0.50) | MAPTALDH1A1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |