Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 16/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 11/20 | 0.58 |
| ▸ | OPRD1 | P41143 | 11/20 | 0.58 |
| ▸ | OPRK1 | P41145 | 11/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21077988 | 0.93 | OPRL1 (0.51) | OPRL1OPRM1OPRD1OPRK1POLB | |
| SCHEMBL21078157 | 0.80 | OPRM1 (0.55) | OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL21078109 | 0.80 | OPRL1 (0.40) | OPRL1OPRM1OPRD1OPRK1POLB | |
| SCHEMBL21077853 | 0.80 | CCR3 (0.57) | OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL21077856 | 0.80 | OPRM1 (0.55) | OPRL1OPRM1OPRD1OPRK1SIGMAR1 | |
| SCHEMBL10060840 | 0.79 | OPRL1 (0.68) | OPRL1OPRM1OPRD1OPRK1POLB | |
| SCHEMBL7815717 | 0.79 | OPRL1 (0.68) | OPRL1OPRM1OPRD1OPRK1POLB | |
| SCHEMBL3590747 | 0.79 | OPRL1 (0.58) | OPRL1OPRM1OPRD1OPRK1POLB | |
| SCHEMBL21652005 | 0.79 | OPRL1 (0.58) | OPRL1OPRM1OPRD1OPRK1POLB | |
| SCHEMBL153569 | 0.79 | OPRL1 (0.59) | OPRL1OPRM1OPRD1OPRK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022125925-A1 | COMPOSITIONS FOR TREATING DRY AGE-RELATED MACULAR DEGENERATION (AMD) | COGNITION THERAPEUTICS, INC. (US) | 2022-06-16 | — | — | WO | disclosed |
| EP-3145929-B1 | 5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS WHICH ARE JAK INHIBITORS | HOFFMANN LA ROCHE (CH) | 2021-01-13 | — | — | EP | disclosed |
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |