Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.37 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21324795 | 0.84 | HSD11B1 (0.53) | HSD11B1ALDH1A1HPGDTSHRGRM5 | |
| SCHEMBL16565524 | 0.83 | HTT (0.49) | HSD11B1ALDH1A1HPGDTSHRSMN1; SMN2 | |
| SCHEMBL25810400 | 0.80 | HSD11B1 (0.66) | HSD11B1ALDH1A1HPGDTSHRSMN1; SMN2 | |
| SCHEMBL17886610 | 0.79 | HSD11B1 (0.42) | HSD11B1ALDH1A1HPGDTSHRSMN1; SMN2 | |
| SCHEMBL14301397 | 0.76 | HPGD (0.68) | ALDH1A1HPGDTSHRSMN1; SMN2CHRNB2 | |
| SCHEMBL24003553 | 0.76 | LMNA (0.40) | HSD11B1ALDH1A1HPGDTSHRSMN1; SMN2 | |
| SCHEMBL24746586 | 0.76 | HTT (0.62) | HSD11B1ALDH1A1HPGDTSHRSMN1; SMN2 | |
| SCHEMBL24003647 | 0.76 | SMN1; SMN2 (0.46) | HSD11B1ALDH1A1HPGDTSHRSMN1; SMN2 | |
| SCHEMBL21078025 | 0.76 | CHRNB2 (0.52) | HSD11B1ALDH1A1HPGDTSHRCHRNB2 | |
| SCHEMBL17177244 | 0.75 | GRM5 (0.49) | HSD11B1ALDH1A1HPGDTSHRGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |