Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 4/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.58 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.58 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.58 |
| ▸ | CCR1 | P32246 | 5/20 | 0.48 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | PKLR | P30613 | 1/20 | 0.37 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA3 | P07451 | 1/20 | 0.36 |
| ▸ | CA6 | P23280 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | CCR3 | P51677 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4821949 | 0.83 | OPRL1 (0.57) | OPRL1OPRM1OPRD1OPRK1CCR1 | |
| SCHEMBL19226358 | 0.83 | OPRM1 (0.58) | OPRL1OPRM1OPRD1OPRK1CCR1 | |
| SCHEMBL21077929 | 0.81 | CNR2 (0.44) | OPRL1OPRM1OPRD1OPRK1CCR1 | |
| SCHEMBL17886582 | 0.80 | OPRM1 (0.56) | OPRL1OPRM1OPRD1OPRK1CCR1 | |
| SCHEMBL4445503 | 0.80 | OPRM1 (0.54) | OPRL1OPRM1OPRD1OPRK1CCR1 | |
| SCHEMBL517455 | 0.80 | OPRM1 (0.54) | OPRL1OPRM1OPRD1OPRK1CCR1 | |
| SCHEMBL5804044 | 0.79 | OPRL1 (0.58) | OPRL1OPRM1OPRD1OPRK1CCR1 | |
| SCHEMBL249869 | 0.78 | OPRM1 (0.53) | OPRL1OPRM1OPRD1OPRK1CCR1 | |
| SCHEMBL21077856 | 0.77 | OPRM1 (0.55) | OPRL1OPRM1OPRD1OPRK1DRD2 | |
| SCHEMBL21078157 | 0.77 | OPRM1 (0.55) | OPRL1OPRM1OPRD1OPRK1CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |