Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 6/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.44 |
| ▸ | PKLR | P30613 | 1/20 | 0.42 |
| ▸ | CCR1 | P32246 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | ARRB1 | P49407 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17888200 | 0.85 | KMT2A (0.45) | CNR2OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL17886585 | 0.82 | OPRM1 (0.46) | CNR2OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL5387141 | 0.81 | PKLR (0.48) | CNR2OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL21077930 | 0.81 | OPRL1 (0.58) | OPRL1OPRM1OPRD1OPRK1PKLR | |
| SCHEMBL2270824 | 0.80 | DRD2 (0.46) | CNR2OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL21078101 | 0.80 | OPRL1 (0.52) | CNR2OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL612068 | 0.77 | HSD11B1 (0.42) | CNR2PKLRGRIN2BCCR2KCNH2 | |
| SCHEMBL613625 | 0.75 | HSD11B1 (0.38) | CNR2OPRL1OPRM1OPRD1OPRK1 | |
| Ethylene SCHEMBL4673777 | 0.75 | HSD11B1 (0.40) | CNR2OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL21077926 | 0.75 | OPRL1 (0.58) | OPRL1OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |