Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 2/20 | 0.41 |
| ▸ | CES1 | P23141 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16116721 | 0.77 | HPGD (0.55) | BLMHPGDALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL15617689 | 0.75 | HPGD (0.53) | BLMHPGDALDH1A1SMN1; SMN2ACHE | |
| SCHEMBL11713669 | 0.72 | SIGMAR1 (0.51) | BLMHPGDALDH1A1KMT2AMEN1 | |
| SCHEMBL9928306 | 0.72 | BLM (0.59) | BLMHPGDALDH1A1ACHESIGMAR1 | |
| SCHEMBL20970963 | 0.72 | CHRM2 (0.58) | BLMHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL10722663 | 0.71 | DRD2 (0.69) | BLMALDH1A1KMT2AMEN1HRH2 | |
| SCHEMBL13596968 | 0.71 | NAMPT (0.57) | BLMHPGDALDH1A1ACHE | |
| SCHEMBL8164455 | 0.71 | TSHR (0.53) | HPGDALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL30634133 | 0.70 | HPGD (0.56) | HPGDALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL16980657 | 0.70 | SIGMAR1 (0.72) | BLMALDH1A1KMT2AMEN1HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |