Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.50 |
| ▸ | KDM1A | O60341 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17888293 | 0.90 | HDAC1 (0.60) | PIK3CAHDAC1SMN1; SMN2LMNAPOLB | |
| SCHEMBL19226518 | 0.85 | LMNA (0.66) | LMNAMEN1KMT2ANAMPTCYP1A2 | |
| SCHEMBL19226517 | 0.84 | SMN1; SMN2 (0.59) | PIK3CAHDAC1SMN1; SMN2LMNAPOLB | |
| SCHEMBL18617541 | 0.82 | TRPV1 (0.53) | PIK3CAHDAC1SMN1; SMN2LMNAPOLB | |
| SCHEMBL27220658 | 0.82 | EPHX2 (0.61) | SMN1; SMN2LMNAHPGDMAPK1MMP13 | |
| SCHEMBL21214344 | 0.82 | PIK3CA (0.48) | PIK3CAHDAC1SMN1; SMN2LMNAPOLB | |
| SCHEMBL10076246 | 0.79 | TRPV1 (0.74) | SMN1; SMN2LMNAPOLBHPGDGLA | |
| SCHEMBL12058757 | 0.78 | LMNA (0.69) | SMN1; SMN2LMNAPOLBHPGDMAPK1 | |
| SCHEMBL19322933 | 0.76 | CYP2C9 (0.48) | PIK3CANAMPTCYP2C9GAAMAPT | |
| SCHEMBL8374098 | 0.76 | L3MBTL1 (0.71) | SMN1; SMN2LMNAPOLBHPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |