Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.74 |
| ▸ | LMNA | P02545 | 5/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.73 |
| ▸ | HTT | P42858 | 3/20 | 0.73 |
| ▸ | MAPT | P10636 | 1/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.72 |
| ▸ | GAA | P10253 | 1/20 | 0.71 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | POLB | P06746 | 3/20 | 0.68 |
| ▸ | HPGD | P15428 | 2/20 | 0.68 |
| ▸ | GLA | P06280 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | MMP13 | P45452 | 1/20 | 0.67 |
| ▸ | CA2 | P00918 | 1/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.65 |
| ▸ | NAMPT | P43490 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8372128 | 0.87 | TSHR (0.74) | TRPV1LMNAALDH1A1HTTMAPT | |
| SCHEMBL29437161 | 0.87 | MMP13 (0.85) | TRPV1LMNAALDH1A1HTTMAPT | |
| SCHEMBL13102334 | 0.87 | MMP13 (0.85) | TRPV1LMNAALDH1A1HTTMAPT | |
| SCHEMBL13766380 | 0.86 | HDAC2 (0.63) | TRPV1LMNAALDH1A1HTTMAPT | |
| SCHEMBL14030202 | 0.86 | L3MBTL1 (0.64) | TRPV1LMNAALDH1A1HTTMAPT | |
| SCHEMBL5257811 | 0.85 | LMNA (0.72) | TRPV1LMNAALDH1A1HTTMAPT | |
| SCHEMBL6569317 | 0.85 | LMNA (0.72) | TRPV1LMNAALDH1A1HTTMAPT | |
| SCHEMBL12334915 | 0.85 | POLB (0.86) | TRPV1ALDH1A1HTTPOLBSMN1; SMN2 | |
| SCHEMBL1161997 | 0.85 | NAMPT (0.75) | TRPV1LMNAALDH1A1HTTMAPT | |
| SCHEMBL1568226 | 0.85 | ALDH1A1 (0.72) | TRPV1LMNAALDH1A1HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093231-B2 | Sulfonylethyl phosphorodiamidates | TELIK, INC. (US) | 2012-01-10 | — | — | US | disclosed |
| US-7667036-B2 | MAPKAP-K2 (mitogen-activated protein kinase-activated protein kinase 2) inhibitors; inflammatory, autoimmune disease, destructive bone disorder, cancer and/or tumor growth; angiogenesis, diabetes and neurological disorders | TEIJIN PHARMA LIMITED (JP) | 2010-02-23 | — | — | US | disclosed |
| US-20080039429-A1 | SULFONYLETHYL PHOSPHORODIAMIDATES | TELIK, INC. | 2008-02-14 | — | — | US | disclosed |
| US-7262182-B2 | Sulfonylethyl phosphorodiamidates | TELIK, INC. (US) | 2007-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039429-A1 | SULFONYLETHYL PHOSPHORODIAMIDATES | MTAP, TYMP, PHOSPHO1 | TRPV1 3876/4885LMNA 3943/4885ALDH1A1 4455/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.