Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL3 | Q96JM7 | 3/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.56 |
| ▸ | GABRD | O14764 | 1/20 | 0.52 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.52 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.52 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.52 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.52 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.52 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.52 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.52 |
| ▸ | NAMPT | P43490 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17888472 | 0.92 | GABRD (0.61) | L3MBTL3L3MBTL1GABRDGABRA1GABRB1 | |
| SCHEMBL17888334 | 0.89 | NAMPT (0.56) | L3MBTL3L3MBTL1NAMPTHSD17B10ALDH1A1 | |
| SCHEMBL17888418 | 0.86 | GABRD (0.71) | L3MBTL3L3MBTL1GABRDGABRA1GABRB1 | |
| SCHEMBL6634743 | 0.83 | HSD17B10 (0.60) | L3MBTL3L3MBTL1GABRDGABRA1GABRB1 | |
| SCHEMBL17886797 | 0.82 | HPGD (0.61) | L3MBTL3L3MBTL1GABRDGABRA1GABRB1 | |
| SCHEMBL21078284 | 0.81 | L3MBTL3 (0.58) | L3MBTL3L3MBTL1GABRDGABRA1GABRB1 | |
| SCHEMBL19226553 | 0.80 | GABRD (0.61) | L3MBTL3L3MBTL1GABRDGABRA1GABRB1 | |
| SCHEMBL17888477 | 0.79 | GABRD (0.64) | L3MBTL3L3MBTL1GABRDGABRA1GABRB1 | |
| SCHEMBL10260239 | 0.78 | SIGMAR1 (0.62) | GABRDGABRA1GABRB1GABRA5GABRA3 | |
| SCHEMBL16565827 | 0.78 | GABRD (0.84) | L3MBTL3L3MBTL1GABRDGABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |