Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16565570 | 0.86 | TSHR (0.55) | HTR2AHTR2CKMT2ATSHRSMN1; SMN2 | |
| SCHEMBL16553664 | 0.82 | GRIN2D (0.46) | HTR2AHTR2CKMT2ATSHRSMN1; SMN2 | |
| SCHEMBL28077641 | 0.82 | TSHR (0.44) | HTR2AHTR2CKMT2ATSHRSMN1; SMN2 | |
| SCHEMBL16565682 | 0.78 | KMT2A (0.43) | HTR2AHTR2CKMT2ATSHRSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL16553822 | 0.77 | KMT2A (0.42) | HTR2AHTR2CKMT2ATSHRSMN1; SMN2 | |
| SCHEMBL16565507 | 0.75 | RORC (0.47) | TSHR | |
| SCHEMBL17867827 | 0.73 | SMN1; SMN2 (0.37) | HTR2AHTR2CKMT2ATSHRSMN1; SMN2 | |
| SCHEMBL19226574 | 0.71 | PARG (0.48) | — | |
| SCHEMBL20198535 | 0.66 | POLB (0.67) | KMT2ATSHRSMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL7760437 | 0.65 | APOBEC3G (0.54) | HTR2AHTR2CKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |