Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | PKM | P14618 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.57 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3830424 | 0.89 | POLB (0.80) | POLBPKMALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL7122592 | 0.89 | POLB (0.80) | POLBPKMALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL735657 | 0.89 | POLB (0.80) | POLBPKMALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL4526586 | 0.82 | POLB (0.69) | POLBPKMALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL7469413 | 0.82 | PKM (0.72) | POLBPKMALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL6805741 | 0.81 | ALDH1A1 (0.81) | POLBPKMALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL1988224 | 0.81 | ALDH1A1 (0.81) | POLBPKMALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL14470279 | 0.81 | ALDH1A1 (0.75) | POLBPKMALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL19457355 | 0.81 | PKM (0.73) | POLBPKMALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL20458879 | 0.80 | POLB (0.67) | POLBPKMALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3033336-B1 | INHIBITORS OF PLASMA KALLIKREIN | KALVISTA PHARMACEUTICALS LTD (GB) | 2018-05-30 | — | — | EP | disclosed |