Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 2/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | DRD4 | P21917 | 1/20 | 0.56 |
| ▸ | P2RX7 | Q99572 | 10/20 | 0.53 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16565532 | 0.88 | P2RX7 (0.67) | DRD3DRD2DRD4P2RX7MCHR1 | |
| SCHEMBL21214320 | 0.84 | DRD3 (0.54) | DRD3DRD2DRD4P2RX7MCHR1 | |
| SCHEMBL20004196 | 0.84 | DRD2 (0.54) | DRD3DRD2DRD4P2RX7MCHR1 | |
| SCHEMBL16553711 | 0.81 | DRD2 (0.53) | DRD3DRD2DRD4P2RX7MCHR1 | |
| SCHEMBL16554105 | 0.79 | DRD2 (0.50) | DRD3DRD2DRD4P2RX7MCHR1 | |
| SCHEMBL28077553 | 0.79 | DRD2 (0.50) | DRD3DRD2DRD4P2RX7MCHR1 | |
| SCHEMBL21078155 | 0.77 | EPHX2 (0.43) | DRD3DRD2DRD4P2RX7SLC6A2 | |
| SCHEMBL21078008 | 0.76 | DRD2 (0.49) | DRD3DRD2DRD4P2RX7SLC6A2 | |
| SCHEMBL21078137 | 0.76 | SLC6A4 (0.41) | DRD2P2RX7SLC6A4SLC6A3 | |
| SCHEMBL11602483 | 0.75 | DRD4 (0.55) | DRD3DRD2DRD4P2RX7CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |