Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.50 |
| ▸ | DRD3 | P35462 | 2/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 7/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20004196 | 0.84 | DRD2 (0.54) | DRD2DRD3DRD4P2RX7TSHR | |
| SCHEMBL28831246 | 0.83 | SLC6A4 (0.48) | DRD2P2RX7 | |
| SCHEMBL16554105 | 0.82 | DRD2 (0.50) | DRD2DRD3DRD4P2RX7TSHR | |
| SCHEMBL28077739 | 0.81 | DRD2 (0.39) | DRD2P2RX7CNR1 | |
| SCHEMBL28077613 | 0.81 | DRD2 (0.39) | DRD2P2RX7CNR1 | |
| SCHEMBL28077873 | 0.81 | DRD2 (0.39) | DRD2P2RX7CNR1 | |
| SCHEMBL16565532 | 0.80 | P2RX7 (0.67) | DRD2DRD3DRD4P2RX7MCHR1 | |
| SCHEMBL21078014 | 0.79 | DRD3 (0.56) | DRD2DRD3DRD4P2RX7TSHR | |
| SCHEMBL28077607 | 0.79 | EPHX2 (0.45) | DRD2P2RX7CNR1 | |
| SCHEMBL373464 | 0.78 | DRD3 (0.48) | DRD2DRD3DRD4P2RX7KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105745209-A | Triazolopyridine compounds, compositions, and methods of use thereof | 豪夫迈·罗氏有限公司 | 2016-07-06 | — | — | CN | disclosed |