Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.56 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.56 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.55 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.53 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17888296 | 0.89 | KDM4E (0.63) | ALDH1A1KDM4EKMT2AMEN1HPGD | |
| SCHEMBL19226713 | 0.86 | KDM4E (0.60) | ALDH1A1KDM4EKMT2AMEN1HPGD | |
| SCHEMBL17886719 | 0.86 | KDM4E (0.60) | ALDH1A1KDM4EKMT2AMEN1HPGD | |
| SCHEMBL27603665 | 0.85 | CHRNB2 (0.62) | ALDH1A1KDM4EKMT2AMEN1HPGD | |
| SCHEMBL17888397 | 0.85 | ALDH1A1 (0.59) | ALDH1A1KDM4EKMT2AMEN1TDP1 | |
| SCHEMBL31430919 | 0.83 | CHRNB2 (0.59) | ALDH1A1KDM4EKMT2AMEN1HPGD | |
| SCHEMBL1962198 | 0.83 | CHRNB2 (0.59) | ALDH1A1KDM4EKMT2AMEN1HPGD | |
| SCHEMBL13024504 | 0.83 | CHRNB2 (0.63) | ALDH1A1KDM4EKMT2AMEN1HPGD | |
| SCHEMBL19226526 | 0.82 | ALDH1A1 (0.56) | ALDH1A1KDM4EKMT2AMEN1HPGD | |
| SCHEMBL17886675 | 0.82 | ALDH1A1 (0.56) | ALDH1A1KDM4ETDP1CHRNB2CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |