Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.59 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.59 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.55 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.55 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | APEX1 | P27695 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17888397 | 0.96 | ALDH1A1 (0.59) | KDM4EALDH1A1PRMT5WDR77GPBAR1 | |
| SCHEMBL21078063 | 0.89 | ALDH1A1 (0.64) | KDM4EALDH1A1PRMT5WDR77GPBAR1 | |
| SCHEMBL17886719 | 0.87 | KDM4E (0.60) | KDM4EALDH1A1PRMT5WDR77GPBAR1 | |
| SCHEMBL19226713 | 0.87 | KDM4E (0.60) | KDM4EALDH1A1PRMT5WDR77GPBAR1 | |
| SCHEMBL5909347 | 0.85 | ALDH1A1 (0.59) | KDM4EALDH1A1PRMT5WDR77GPBAR1 | |
| SCHEMBL19226526 | 0.84 | ALDH1A1 (0.56) | KDM4EALDH1A1GPBAR1KMT2ALMNA | |
| SCHEMBL17886675 | 0.84 | ALDH1A1 (0.56) | KDM4EALDH1A1PRMT5WDR77GPBAR1 | |
| SCHEMBL13024504 | 0.82 | CHRNB2 (0.63) | KDM4EALDH1A1PRMT5WDR77GPBAR1 | |
| SCHEMBL14304391 | 0.82 | PRMT5 (0.55) | KDM4EALDH1A1PRMT5WDR77GPBAR1 | |
| SCHEMBL27603665 | 0.82 | CHRNB2 (0.62) | KDM4EALDH1A1PRMT5WDR77KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170226132-A1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2017-08-10 | — | — | US | disclosed |
| US-20160185780-A1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2016-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160185780-A1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | ABL1, JAK2, JAK1 | KDM4E 1708/4885ALDH1A1 1339/4885PRMT5 1107/4885 |
| US-20170226132-A1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | ABL1, JAK2, JAK1 | KDM4E 1708/4885ALDH1A1 1339/4885PRMT5 1107/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.