Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | KDM1A | O60341 | 3/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17888239 | 0.81 | OPRK1 (0.38) | HSD17B10SIGMAR1OPRM1SLC18A3TSHR | |
| SCHEMBL8202443 | 0.80 | TRPV1 (0.49) | HSD17B10TSHRUSP2CYP2D6CYP3A4 | |
| SCHEMBL17886562 | 0.79 | TRPV1 (0.36) | HSD17B10SIGMAR1OPRM1SLC18A3TSHR | |
| SCHEMBL21788683 | 0.78 | TRPV1 (0.37) | HSD17B10SIGMAR1OPRM1SLC18A3TSHR | |
| SCHEMBL8212506 | 0.72 | ALDH1A1 (0.43) | HSD17B10TRPV1 | |
| SCHEMBL26669761 | 0.71 | SLC18A3 (0.41) | SIGMAR1SLC18A3KDM1AMAOBCYP3A4 | |
| SCHEMBL24621328 | 0.70 | TSHR (0.40) | HSD17B10SIGMAR1OPRM1SLC18A3TSHR | |
| SCHEMBL18746129 | 0.69 | MAPT (0.42) | HSD17B10SIGMAR1OPRM1SLC18A3TSHR | |
| SCHEMBL8202509 | 0.68 | TSHR (0.41) | HSD17B10SIGMAR1OPRM1SLC18A3TSHR | |
| SCHEMBL1138335 | 0.67 | SLC6A9 (0.56) | OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |