Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 5/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21077993 | 0.84 | POLB (0.42) | MEN1KMT2ACNR1NAMPTALDH1A1 | |
| SCHEMBL17888240 | 0.83 | MEN1 (0.41) | MEN1KMT2ACNR1CNR2NAMPT | |
| SCHEMBL21077998 | 0.83 | NAMPT (0.45) | MEN1KMT2ANAMPTALDH1A1 | |
| SCHEMBL21077810 | 0.82 | MEN1 (0.45) | MEN1KMT2ACNR1NAMPTJAK1 | |
| SCHEMBL17886559 | 0.81 | CNR1 (0.45) | MEN1KMT2ACNR1CNR2NAMPT | |
| SCHEMBL21077996 | 0.80 | L3MBTL1 (0.45) | MEN1KMT2ANAMPT | |
| SCHEMBL21077809 | 0.79 | MEN1 (0.40) | MEN1KMT2ANAMPTJAK2JAK1 | |
| SCHEMBL21078127 | 0.76 | MEN1 (0.40) | MEN1KMT2ACNR1NAMPTJAK2 | |
| SCHEMBL21077850 | 0.76 | JAK1 (0.48) | MEN1KMT2AJAK2JAK1 | |
| SCHEMBL21078125 | 0.76 | NAMPT (0.43) | NAMPTKCNH2HRH3ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |