Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 5/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21078097 | 0.84 | MEN1 (0.40) | NAMPTALDH1A1KMT2AMEN1CNR1 | |
| SCHEMBL14243055 | 0.82 | ATM (0.46) | POLBNAMPTL3MBTL1NPSR1ATM | |
| SCHEMBL17886549 | 0.79 | POLB (0.41) | POLBNAMPTL3MBTL1NPSR1ATM | |
| SCHEMBL21077998 | 0.79 | NAMPT (0.45) | POLBNAMPTL3MBTL1ALDH1A1KMT2A | |
| SCHEMBL21078125 | 0.78 | NAMPT (0.43) | NAMPTNPSR1ALDH1A1NPC1RAB9A | |
| SCHEMBL21077810 | 0.78 | MEN1 (0.45) | NAMPTATMALDH1A1KMT2AMEN1 | |
| SCHEMBL21077807 | 0.77 | GRM1 (0.44) | NAMPTKMT2AMEN1CNR1 | |
| SCHEMBL21077916 | 0.77 | MEN1 (0.40) | ALDH1A1KMT2AMEN1RAB9A | |
| SCHEMBL21077861 | 0.76 | NAMPT (0.43) | NAMPTKMT2AMEN1CNR1 | |
| SCHEMBL21077996 | 0.76 | L3MBTL1 (0.45) | POLBNAMPTL3MBTL1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |