Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.40 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.40 |
| ▸ | GPR183 | P32249 | 1/20 | 0.39 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21077998 | 0.90 | NAMPT (0.45) | L3MBTL1MEN1KMT2ATDP1NAMPT | |
| SCHEMBL21077810 | 0.83 | MEN1 (0.45) | MEN1KMT2ATDP1NAMPTNPC1 | |
| SCHEMBL17888227 | 0.83 | L3MBTL1 (0.46) | L3MBTL1MEN1KMT2ATDP1NAMPT | |
| SCHEMBL17886547 | 0.80 | L3MBTL1 (0.44) | L3MBTL1MEN1KMT2ATDP1NAMPT | |
| SCHEMBL21077809 | 0.80 | MEN1 (0.40) | MEN1KMT2ANAMPT | |
| SCHEMBL21078097 | 0.80 | MEN1 (0.40) | MEN1KMT2ANAMPT | |
| SCHEMBL21078127 | 0.77 | MEN1 (0.40) | MEN1KMT2ANAMPT | |
| SCHEMBL21077850 | 0.77 | JAK1 (0.48) | MEN1KMT2ANPC1 | |
| SCHEMBL21077807 | 0.76 | GRM1 (0.44) | MEN1KMT2ANAMPT | |
| SCHEMBL21077993 | 0.76 | POLB (0.42) | L3MBTL1MEN1KMT2ANAMPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |