Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28467446 | 1.00 | GAA (0.32) | GAA | |
| SCHEMBL21304073 | 1.00 | GAA (0.32) | GAA | |
| SCHEMBL29183099 | 0.70 | GAA (0.31) | GAA | |
| SCHEMBL22732857 | 0.69 | DGAT1 (0.31) | — | |
| SCHEMBL16056817 | 0.68 | DGAT1 (0.32) | — | |
| SCHEMBL30008546 | 0.62 | — | — | |
| SCHEMBL23575974 | 0.60 | MEN1 (0.34) | — | |
| SCHEMBL32667735 | 0.55 | PKM (0.37) | — | |
| SCHEMBL17164996 | 0.55 | GAA (0.41) | GAA | |
| SCHEMBL1515542 | 0.54 | DGAT1 (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12275724-B2 | Processes and intermediates for the preparation of soluble guanylate cyclase stimulators | CYCLERION THERAPEUTICS, INC. (US) | 2025-04-15 | — | — | US | disclosed |
| US-20240391911-A1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF SOLUBLE GUANYLATE CYCLASE STIMULATORS | CYCLERION THERAPEUTICS, INC. | 2024-11-28 | — | — | US | disclosed |
| US-12030874-B2 | Processes and intermediates for the preparation of soluble guanylate cyclase stimulators | CYCLERION THERAPEUTICS, INC. (US) | 2024-07-09 | — | — | US | disclosed |
| US-12030874-B2 | Processes and intermediates for the preparation of soluble guanylate cyclase stimulators | CYCLERION THERAPEUTICS, INC. (US) | 2024-07-09 | — | — | US | disclosed |
| CN-118221665-A | Methods and intermediates for preparing soluble guanylate cyclase stimulators | 赛克里翁治疗有限公司 | 2024-06-21 | — | — | CN | disclosed |
| CN-118184645-A | Methods and intermediates for preparing soluble guanylate cyclase stimulators | 赛克里翁治疗有限公司 | 2024-06-14 | — | — | CN | disclosed |
| CN-111902410-B | Methods and intermediates for preparing soluble guanylate cyclase stimulators | 赛克里翁治疗有限公司 | 2024-04-19 | — | — | CN | disclosed |
| CN-111712247-B | sGC stimulators | 塞科里昂医疗股份有限公司 | 2024-02-09 | — | — | CN | disclosed |
| US-11834444-B2 | Processes for preparation of soluble guanylate cyclase stimulators | CYCLERION THERAPEUTICS, INC. (US) | 2023-12-05 | — | — | US | disclosed |
| US-11834444-B2 | Processes for preparation of soluble guanylate cyclase stimulators | CYCLERION THERAPEUTICS, INC. (US) | 2023-12-05 | — | — | US | disclosed |
| US-20220024909-A1 | NOVEL PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF SOLUBLE GUANYLATE CYCLASE STIMULATORS | CYCLERION THERAPEUTICS, INC. | 2022-01-27 | — | — | US | disclosed |
| US-20210284632-A1 | NOVEL PROCESSES FOR PREPARATION OF SOLUBLE GUANYLATE CYCLASE STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. | 2021-09-16 | — | — | US | disclosed |
| US-20210188830-A1 | SOLID FORMS OF AN SGC STIMULATOR | CYCLERION THERAPEUTICS, INC. | 2021-06-24 | — | — | US | disclosed |
| US-20210053962-A1 | NOVEL PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF SOLUBLE GUANYLATE CYCLASE STIMULATORS | CYCLERION THERAPEUTICS, INC. | 2021-02-25 | — | — | US | disclosed |
| US-10889577-B2 | Solid forms of an sGC stimulator | CYCLERION THERAPEUTICS, INC. (US) | 2021-01-12 | — | — | US | disclosed |
| US-20200377508-A1 | sGC STIMULATORS | TISENTO THERAPEUTICS INC. | 2020-12-03 | — | — | US | disclosed |
| CN-111902410-A | Novel process and intermediates for the preparation of soluble guanylate cyclase stimulators | 赛克里翁治疗有限公司 | 2020-11-06 | — | — | CN | disclosed |
| CN-111712247-A | sGC stimulators | 塞科里昂医疗股份有限公司 | 2020-09-25 | — | — | CN | disclosed |
| WO-2019161534-A1 | NOVEL PROCESSES AND INTERMEDIATES FOR PREPARATION OF SOLUBLE GUANYLATE CYCLASE STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2019-08-29 | — | — | WO | disclosed |
| US-20190169179-A1 | SOLID FORMS OF AN SGC STIMULATOR | IRONWOOD PHARMACEUTICALS, INC. | 2019-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12275724-B2 | Processes and intermediates for the preparation of soluble guanylate cyclase stimulators | GUCY1A2, GUCY1B1, GUCY1B2 | GAA 1412/4885 |
| US-10889577-B2 | Solid forms of an sGC stimulator | GUCY1A2, PRKG1, GUCY1A1 | GAA 127/4885 |
| US-20210284632-A1 | NOVEL PROCESSES FOR PREPARATION OF SOLUBLE GUANYLATE CYCLASE STIMULATORS | GUCY1B1, GUCY1B2, GUCY1A2 | GAA 1470/4885 |
| US-20190169179-A1 | SOLID FORMS OF AN SGC STIMULATOR | GUCY1A2, PRKG1, GUCY1A1 | GAA 130/4885 |
| US-20220024909-A1 | NOVEL PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF SOLUBLE GUANYLATE CYCLASE STIMULATORS | GUCY1A2, GUCY1B2, GUCY1B1 | GAA 1276/4885 |
| US-20200377508-A1 | sGC STIMULATORS | GMPS, GUCY1A2, PDE2A | GAA 207/4885 |
| US-20210188830-A1 | SOLID FORMS OF AN SGC STIMULATOR | GUCY1A2, PRKG1, GUCY1A1 | GAA 123/4885 |
| US-20210053962-A1 | NOVEL PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF SOLUBLE GUANYLATE CYCLASE STIMULATORS | GUCY1A2, GUCY1B1, GUCY1B2 | GAA 1189/4885 |
| US-12030874-B2 | Processes and intermediates for the preparation of soluble guanylate cyclase stimulators | GUCY1A2, GUCY1B1, GUCY1B2 | GAA 1412/4885 |
| US-11834444-B2 | Processes for preparation of soluble guanylate cyclase stimulators | GUCY1B1, GUCY1B2, GUCY1A2 | GAA 1612/4885 |
| US-20240391911-A1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF SOLUBLE GUANYLATE CYCLASE STIMULATORS | GUCY1A2, GUCY1B1, GUCY1B2 | GAA 1412/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.