Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | MAT2A | P31153 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | KMO | O15229 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5213850 | 0.88 | BACE1 (0.38) | KDM4ELMNAPSMB5HTTBACE1 | |
| SCHEMBL19537423 | 0.82 | BACE1 (0.41) | KDM5AALDH1A1KDM4ELMNAHPGD | |
| SCHEMBL18677138 | 0.80 | PDGFRB (0.40) | KDM5AALDH1A1KDM4ELMNAHPGD | |
| SCHEMBL14082026 | 0.77 | KDM5A (0.40) | KDM5AALDH1A1KDM4ELMNAHPGD | |
| SCHEMBL16573748 | 0.74 | PROKR1 (0.39) | KDM5AALDH1A1KDM4ELMNAHPGD | |
| SCHEMBL21986515 | 0.72 | ALDH1A1 (0.38) | ALDH1A1KDM4ELMNAPSMB5HTT | |
| SCHEMBL15216874 | 0.71 | TLR9 (0.40) | ALDH1A1KDM4EHPGDCHRM4HTT | |
| SCHEMBL19531853 | 0.71 | KDM5A (0.45) | KDM5AALDH1A1KDM4ELMNAHPGD | |
| SCHEMBL29951678 | 0.70 | PDE10A (0.38) | CHRM4 | |
| SCHEMBL19531802 | 0.69 | KDM5A (0.44) | KDM5AALDH1A1KDM4ELMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3191451-B1 | 4-SUBSTITUTED PYRIDINE-2,6-DICARBOXYLIC ACID DERIVATIVES AND METHOD OF PREPARING SAME | OKINAWA INST SCIENCE & TECH SCHOOL CORP (JP) | 2019-06-05 | — | — | EP | disclosed |