SCHEMBL5213850

SCHEMBL5213850

O=Cc1cc(C2CCCCC2)cc(C=O)n1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BACE1 P56817 1/20 0.38
CYP11B2 P19099 1/20 0.36
KMO O15229 1/20 0.36
HTT P42858 2/20 0.35
KMT2A Q03164 2/20 0.35
TDP1 Q9NUW8 2/20 0.35
ACMSD Q8TDX5 2/20 0.35
KDM4E B2RXH2 1/20 0.35
GLA P06280 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
HIF1A Q16665 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
LMNA P02545 1/20 0.35
HSP90AA1 P07900 1/20 0.34
GAA P10253 1/20 0.34
MAPT P10636 1/20 0.34
PSMB5 P28074 2/20 0.33
HDAC4 P56524 1/20 0.33
HDAC2 Q92769 1/20 0.33
HDAC8 Q9BY41 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21079116 0.88 KDM5A (0.37) BACE1CYP11B2KMOHTTKDM4E
SCHEMBL778084 0.75 CYP11B2 (0.46) BACE1CYP11B2KMOHTTKMT2A
SCHEMBL20633629 0.72 DHODH (0.34) BACE1KMODHODH
SCHEMBL778085 0.72 HDAC8 (0.43) BACE1CYP11B2KMOHTTKMT2A
SCHEMBL15172959 0.72 KMO (0.36) CYP11B2KMOHTTKMT2ATDP1
SCHEMBL29957390 0.72 KDM4E (0.38) HTTKDM4ESMN1; SMN2MAPTEPHX2
SCHEMBL21986515 0.71 ALDH1A1 (0.38) KMOHTTKMT2ATDP1ACMSD
SCHEMBL19537423 0.68 BACE1 (0.41) BACE1CYP11B2HTTKDM4ELMNA
SCHEMBL16573747 0.68 BACE1 (0.41) BACE1CYP11B2KMOHTTKMT2A
SCHEMBL18003336 0.68 ALDH1A1 (0.36) SMN1; SMN2L3MBTL1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1420019-B1 Substituted pyridino pentaazamacrocyle ligands MONSANTO CO (US) 2007-07-25 EP disclosed
EP-1420022-B1 Use of substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity MONSANTO CO (US) 2007-07-04 EP disclosed
EP-1212323-B1 SUBSTITUTED PYRIDINO PENTAAZAMACROCYLE COMPLEXES HAVING SUPEROXIDE DISMUTASE ACTIVITY MONSANTO CO (US) 2004-06-09 EP disclosed
EP-1420022-A1 Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity MONSANTO COMPANY (US) 2004-05-19 EP disclosed
EP-1420019-A1 Substituted pyridino pentaazamacrocyle ligands having superoxide dismutase activity MONSANTO COMPANY (US) 2004-05-19 EP disclosed
WO-2001019823-A9 SUBSTITUTED PYRIDINO PENTAAZAMACROCYLE COMPLEXES HAVING SUPEROXIDE DISMUTASE ACTIVITY MONSANTO CO (US) 2002-09-26 WO disclosed
EP-1212323-A2 SUBSTITUTED PYRIDINO PENTAAZAMACROCYLE COMPLEXES HAVING SUPEROXIDE DISMUTASE ACTIVITY MONSANTO COMPANY (US) 2002-06-12 EP disclosed
US-6214817-B1 NITROGEN MACROCYCLE COMPLEXES WITH MANGANESE AND IRON MONSANTO COMPANY 2001-04-10 US disclosed
WO-2001019823-A2 SUBSTITUTED PYRIDINO PENTAAZAMACROCYLE COMPLEXES HAVING SUPEROXIDE DISMUTASE ACTIVITY MONSANTO COMPANY (US) 2001-03-22 WO disclosed