Belarizine

Belarizine

SCHEMBL2108057

Oc1ccc(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)cc1

nearest known ligand 0.74

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATM Q13315 2/20 0.73
MEN1 O00255 3/20 0.68
KMT2A Q03164 3/20 0.68
KCNH2 Q12809 3/20 0.65
HDAC1 Q13547 2/20 0.65
HDAC4 P56524 1/20 0.65
OPRD1 P41143 2/20 0.60
ADORA3 P0DMS8 2/20 0.60
CNR1 P21554 2/20 0.60
HRH1 P35367 2/20 0.60
OPRK1 P41145 2/20 0.60
GHSR Q92847 2/20 0.60
LMNA P02545 1/20 0.60
NR1I2 O75469 1/20 0.60
PDE4D Q08499 1/20 0.60
DRD4 P21917 2/20 0.56
OPRM1 P35372 2/20 0.56
CYP3A4 P08684 2/20 0.55
USP2 O75604 1/20 0.55
CYP1A2 P05177 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9720751 0.93 KCNH2 (0.71) ATMMEN1KMT2AKCNH2HDAC1
SCHEMBL7311276 0.89 ATM (0.84) ATMMEN1KMT2AKCNH2HDAC1
Hydrochloric Acid SCHEMBL16226937 0.87 ATM (0.82) ATMMEN1KMT2AKCNH2HDAC1
SCHEMBL9720705 0.86 KCNH2 (0.62) ATMMEN1KMT2AKCNH2HDAC1
SCHEMBL9720786 0.86 ATM (0.59) ATMMEN1KMT2AKCNH2HDAC1
SCHEMBL9720683 0.85 ATM (0.54) ATMMEN1KMT2AKCNH2HDAC1
SCHEMBL9720694 0.85 ATM (0.69) ATMMEN1KMT2AKCNH2ADORA3
SCHEMBL16226852 0.84 MEN1 (0.86) ATMMEN1KMT2AKCNH2HDAC1
SCHEMBL16226642 0.84 ATM (0.68) ATMMEN1KMT2AKCNH2HDAC1
SCHEMBL12464946 0.84 KCNH2 (0.80) ATMMEN1KMT2AKCNH2HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
US-20220047505-A1 Controlled Absorption Water-Soluble Pharmaceutically Active Organic Compound Formulation for Once-Daily Administration STI PHARMA, LLC (US) 2022-02-17 US disclosed
US-11191719-B2 Controlled absorption water-soluble pharmaceutically active organic compound formulation for once-daily administration STI PHARMA, LLC (US) 2021-12-07 US disclosed
US-10463611-B2 Controlled absorption water-soluble pharmaceutically active organic compound formulation for once-daily administration STI PHARMA, LLC (US) 2019-11-05 US disclosed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US disclosed
CN-104496739-A Green catalytic synthesis method of diphenylmethane UNIV LIAONING SHIHUA 2015-04-08 CN disclosed
CN-103508838-B Preparation method of diphenylmethane compounds DALIAN CHEMICAL PHYSICS INST 2015-01-14 CN disclosed
US-20140154313-A1 Controlled Absorption Water-Soluble Pharmaceutically Active Organic Compound Formulation for Once-Daily Administration STI PHARMA, LLC (US) 2014-06-05 US disclosed
US-20020102215-A1 Diagnostic/therapeutic agents NYCOMED IMAGING AS 2002-08-01 US disclosed
US-20020102217-A1 Diagnostic/therapeutic agents NYCOMED IMAGING AS 2002-08-01 US disclosed
US-6331289-B1 ULTRASOUND CONTRAST AGENTS, SUSPENSION IN AQUEOUS CARRIER LIQUID OF A REPORTER COMPRISING GAS-CONTAINING OR GAS-GENERATING MATERIAL, AGENT CAPABLE OF FORMING AT LEAST TWO TYPES OF BINDING PAIRS WITH TARGET; REPORTER BEING CONJUGATED NYCOMED IMAGING AS (NO) 2001-12-18 US disclosed
US-6264917-B1 MIXTURE OF GAS FILLED MICROBUBBLES AND RELEASING AGENT NYCOMED IMAGING AS (NO) 2001-07-24 US disclosed
US-6261537-B1 TARGETS AND ULTRASOUND DIAGNOSIS OF ACTIVE MATERIALS, AQUEOUS CARRIER LIQUIDS, CARRIERS AND FILM FORMING SURFACTANT PHOSPHATIDES NYCOMED IMAGING AS (NO) 2001-07-17 US disclosed
EP-0682664-B1 COMPOUNDS HAVING BOTH POTENT CALCIUM ANTAGONIST AND ANTIOXIDANT ACTIVITY AND USE THEREOF AS CYTOPROTECTIVE AGENTS ALCON LAB INC (US) 2001-03-14 EP disclosed
US-5142052-A Cationic effect-driven carbinol/amine reaction LABORATOIRES SYNTEX (FR) 1992-08-25 US disclosed
US-3868377-A N-benzhydryl-N{40 -p-hydroxybenzyl-piperazines and processes for their manufacture CASSELLA FARBWERKE MAINKUR AG 1975-02-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020102215-A1 Diagnostic/therapeutic agents BID, FUS, FABP1 ATM 2765/4885MEN1 671/4885KMT2A 4411/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.