SCHEMBL9720786

SCHEMBL9720786

Oc1ccc2cc(CN3CCN(C(c4ccccc4)c4ccccc4)CC3)ccc2c1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATM Q13315 2/20 0.59
OPRD1 P41143 1/20 0.57
KMT2A Q03164 3/20 0.56
MEN1 O00255 2/20 0.56
KCNH2 Q12809 3/20 0.54
HDAC1 Q13547 2/20 0.54
HDAC4 P56524 1/20 0.54
CYP3A4 P08684 2/20 0.52
ADORA3 P0DMS8 2/20 0.52
CNR1 P21554 2/20 0.52
HRH1 P35367 2/20 0.52
OPRK1 P41145 2/20 0.52
GHSR Q92847 2/20 0.52
USP2 O75604 1/20 0.52
CYP1A2 P05177 1/20 0.52
CYP2D6 P10635 1/20 0.52
CYP2C19 P33261 1/20 0.52
HPN P05981 1/20 0.52
CHRM2 P08172 1/20 0.52
ADRA2A P08913 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Belarizine SCHEMBL2108057 0.86 ATM (0.73) ATMOPRD1KMT2AMEN1KCNH2
SCHEMBL9720716 0.85 OPRD1 (0.70) ATMOPRD1KMT2AMEN1KCNH2
SCHEMBL9720751 0.80 KCNH2 (0.71) ATMOPRD1KMT2AMEN1KCNH2
SCHEMBL7311276 0.78 ATM (0.84) ATMOPRD1KMT2AMEN1KCNH2
Hydrochloric Acid SCHEMBL16226937 0.77 ATM (0.82) ATMOPRD1KMT2AMEN1KCNH2
SCHEMBL6305023 0.77 HRH3 (0.53) KMT2ASMN1; SMN2PKM
SCHEMBL9720718 0.76 TRPV6 (0.58) ATMKMT2AMEN1LMNAGAA
SCHEMBL13150133 0.76 KMT2A (0.66) KMT2AMEN1HDAC1HDAC4CYP2D6
Bromide SCHEMBL2924741 0.75 HRH3 (0.52) KMT2ASMN1; SMN2PKM
SCHEMBL9720741 0.75 OPRD1 (0.55) ATMOPRD1KMT2AMEN1KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5142052-A Cationic effect-driven carbinol/amine reaction LABORATOIRES SYNTEX (FR) 1992-08-25 US disclosed