Clodoxopone

Clodoxopone

SCHEMBL2108504

O=c1oc(CCN2CCN(c3ccccc3)CC2)c(-c2ccc(Cl)cc2)o1

nearest known ligand 0.54

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 1/20 0.51
SIGMAR1 Q99720 2/20 0.49
HTR1A P08908 3/20 0.48
HTR7 P34969 1/20 0.48
LMNA P02545 2/20 0.47
ADRA1D P25100 1/20 0.47
ADRA1A P35348 1/20 0.47
ADRA1B P35368 1/20 0.47
ALDH1A1 P00352 1/20 0.47
MAPT P10636 1/20 0.47
DRD3 P35462 1/20 0.47
DRD2 P14416 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.46
DRD4 P21917 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Clodoxopone SCHEMBL11473514 0.99 PTGS2 (0.50) PTGS2SIGMAR1HTR1AHTR7LMNA
SCHEMBL11479775 0.94 DRD3 (0.47) PTGS2SIGMAR1HTR1AADRA1DADRA1A
Hydrochloric Acid SCHEMBL11474269 0.93 DRD3 (0.46) PTGS2SIGMAR1HTR1AADRA1DADRA1A
SCHEMBL11473453 0.92 HTR1A (0.50) SIGMAR1HTR1AHTR7ADRA1DADRA1A
SCHEMBL11489388 0.92 HTR1A (0.52) SIGMAR1HTR1AHTR7ADRA1DADRA1A
Hydrochloric Acid SCHEMBL11480179 0.91 HTR1A (0.49) SIGMAR1HTR1AHTR7ADRA1DADRA1A
Hydrochloric Acid SCHEMBL11482472 0.90 HTR1A (0.51) SIGMAR1HTR1AHTR7ADRA1DADRA1A
Fludoxopone SCHEMBL2110611 0.88 DRD2 (0.51) SIGMAR1HTR1ALMNAADRA1DADRA1A
SCHEMBL11473650 0.88 MAPT (0.54) PTGS2SIGMAR1HTR1AHTR7ADRA1D
Fludoxopone SCHEMBL11477891 0.87 DRD2 (0.52) SIGMAR1HTR1ALMNAADRA1DADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250161243-A1 MEF2 TRANSCRIPTIONAL ACTIVATORS TO TREAT NEUROLOGIC CONDITIONS THE SCRIPPS RESEARCH INSTITUTE 2025-05-22 US claimed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
US-4235904-A HYPOCHOLESTEROLEMIC, HYPOLIPEMIC, ANTIULCER, ANTIHISTAMINIC AND ANTISEROTONINIC ACTIVITIES INSTITUTO LUSO FARMACO D'ITALIA S.P.A. (IT) 1980-11-25 US claimed
US-20250161243-A1 MEF2 TRANSCRIPTIONAL ACTIVATORS TO TREAT NEUROLOGIC CONDITIONS THE SCRIPPS RESEARCH INSTITUTE 2025-05-22 US disclosed
US-20220047505-A1 Controlled Absorption Water-Soluble Pharmaceutically Active Organic Compound Formulation for Once-Daily Administration STI PHARMA, LLC (US) 2022-02-17 US disclosed
US-11191719-B2 Controlled absorption water-soluble pharmaceutically active organic compound formulation for once-daily administration STI PHARMA, LLC (US) 2021-12-07 US disclosed
US-10463611-B2 Controlled absorption water-soluble pharmaceutically active organic compound formulation for once-daily administration STI PHARMA, LLC (US) 2019-11-05 US disclosed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US disclosed
US-20140154313-A1 Controlled Absorption Water-Soluble Pharmaceutically Active Organic Compound Formulation for Once-Daily Administration STI PHARMA, LLC (US) 2014-06-05 US disclosed
US-20040141922-A1 Diagnostic/therapeutic agents NYCOMED IMAGING AS 2004-07-22 US disclosed
US-6680047-B2 FOR USE IN ULTRASOUND IMAGING, CONTRAST AGENTS AMERSHAM HEALTH AS (NO) 2004-01-20 US disclosed
US-20020102215-A1 Diagnostic/therapeutic agents NYCOMED IMAGING AS 2002-08-01 US disclosed
US-20020102217-A1 Diagnostic/therapeutic agents NYCOMED IMAGING AS 2002-08-01 US disclosed
US-6331289-B1 ULTRASOUND CONTRAST AGENTS, SUSPENSION IN AQUEOUS CARRIER LIQUID OF A REPORTER COMPRISING GAS-CONTAINING OR GAS-GENERATING MATERIAL, AGENT CAPABLE OF FORMING AT LEAST TWO TYPES OF BINDING PAIRS WITH TARGET; REPORTER BEING CONJUGATED NYCOMED IMAGING AS (NO) 2001-12-18 US disclosed
US-6264917-B1 MIXTURE OF GAS FILLED MICROBUBBLES AND RELEASING AGENT NYCOMED IMAGING AS (NO) 2001-07-24 US disclosed
US-6261537-B1 TARGETS AND ULTRASOUND DIAGNOSIS OF ACTIVE MATERIALS, AQUEOUS CARRIER LIQUIDS, CARRIERS AND FILM FORMING SURFACTANT PHOSPHATIDES NYCOMED IMAGING AS (NO) 2001-07-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040141922-A1 Diagnostic/therapeutic agents BID, FUS, FABP1 PTGS2 2994/4885SIGMAR1 1829/4885HTR1A 3986/4885
US-20250161243-A1 MEF2 TRANSCRIPTIONAL ACTIVATORS TO TREAT NEUROLOGIC CONDITIONS MEF2D, TEAD2, TEAD1 PTGS2 4393/4885SIGMAR1 4379/4885HTR1A 969/4885
US-20020102215-A1 Diagnostic/therapeutic agents BID, FUS, FABP1 PTGS2 3278/4885SIGMAR1 1643/4885HTR1A 4030/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.