Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | GLS | O94925 | 2/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21085394 | 1.00 | HPGD (0.49) | HPGDPOLBALDH1A1GLSF2 | |
| SCHEMBL21085393 | 1.00 | HPGD (0.49) | HPGDPOLBALDH1A1GLSF2 | |
| SCHEMBL10130895 | 0.81 | HPGD (0.53) | HPGDPOLBALDH1A1GLSF2 | |
| SCHEMBL10954825 | 0.78 | HPGD (0.50) | HPGDPOLBALDH1A1GLSF2 | |
| SCHEMBL11723966 | 0.78 | HPGD (0.50) | HPGDPOLBALDH1A1GLSF2 | |
| SCHEMBL21085352 | 0.76 | ALDH1A1 (0.42) | HPGDPOLBALDH1A1HSD17B10 | |
| SCHEMBL19859558 | 0.76 | ALDH1A1 (0.42) | HPGDPOLBALDH1A1HSD17B10 | |
| SCHEMBL19859560 | 0.76 | ALDH1A1 (0.42) | HPGDPOLBALDH1A1HSD17B10 | |
| SCHEMBL27875748 | 0.76 | HPGD (0.45) | HPGDPOLBALDH1A1GLSF2 | |
| SCHEMBL14977352 | 0.73 | POLB (0.52) | HPGDPOLBALDH1A1GLSF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190169181-A1 | FUMAGILLOL COMPOUNDS AND METHODS OF MAKING AND USING SAME | ZAFGEN, INC. | 2019-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190169181-A1 | FUMAGILLOL COMPOUNDS AND METHODS OF MAKING AND USING SAME | METAP2, DNPEP, FOLH1 | HPGD 769/4885POLB 1379/4885ALDH1A1 608/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.