⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13334093 | 0.80 | TTR (0.46) | — | |
| SCHEMBL14457145 | 0.68 | ALDH1A1 (0.48) | — | |
| SCHEMBL5926479 | 0.68 | TDP1 (0.42) | — | |
| SCHEMBL8342343 | 0.66 | TDP1 (0.52) | — | |
| SCHEMBL5182053 | 0.66 | ALDH1A1 (0.61) | — | |
| SCHEMBL19498505 | 0.66 | TTR (0.41) | — | |
| SCHEMBL13265882 | 0.65 | CASP1 (0.42) | — | |
| SCHEMBL3780632 | 0.65 | CA1 (0.39) | — | |
| SCHEMBL14467747 | 0.63 | ENPP2 (0.34) | — | |
| SCHEMBL8958922 | 0.63 | KDM4E (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373318-B1 | IMIDAZOPYRAZINE SYK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2019-06-05 | — | — | EP | disclosed |