Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 8/20 | 0.34 |
| ▸ | QRFPR | Q96P65 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | TTK | P33981 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12128199 | 0.92 | APP (0.35) | HTR6PTGDR2 | |
| SCHEMBL12128235 | 0.84 | APP (0.37) | HTR6PTGDR2 | |
| SCHEMBL12128227 | 0.82 | KEAP1 (0.36) | PTGDR2 | |
| SCHEMBL12128127 | 0.82 | PDE4B (0.35) | HTR6PTGDR2 | |
| SCHEMBL12131843 | 0.79 | PTGDR2 (0.36) | PTGDR2TTK | |
| SCHEMBL12127944 | 0.79 | MAPT (0.35) | PTGDR2TTK | |
| SCHEMBL21089058 | 0.78 | PTGDR2 (0.38) | HTR6PTGDR2 | |
| SCHEMBL12127658 | 0.78 | HTR6 (0.41) | HTR6PTGDR2 | |
| SCHEMBL12127951 | 0.77 | GALR1 (0.39) | HTR6PTGDR2 | |
| SCHEMBL12131830 | 0.77 | AKR1C3 (0.36) | HTR6PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558446-B1 | NOVEL COMPOUNDS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH AMYLOID OR AMYLOID-LIKE PROTEINS | AC IMMUNE SA (CH) | 2019-06-12 | — | — | EP | disclosed |